Results 121 to 130 of about 246,572 (299)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Impact of meteorological and processing factors on metabolite composition of Darjeeling tea

Journal of Analytical Science and Technology
Meteorological and edaphic factors significantly affect the first flush metabolite composition of Darjeeling tea, impacting flavor, nutrition, and customer preferences. The Camellia sinensis var.
Dwaipee De, Sreerupa Sarkar, Himashree Chhetri, Jhelam Chatterjee, Nitu Sinha, Sujit Das, Abhijit Sarkar, Susmita Das, Sonali Ray   +8 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Comparison of methods for estimating wild turkey poult survival

Wildlife Society Bulletin
Eastern wild turkey (Meleagris gallopavo silvestris) population growth is driven by variation in reproduction, and poult survival is a crucial vital rate. Traditional poult survival monitoring uses flush counts of radio‐tagged females, but brood flocking
Joseph O. Quehl, Lindsey M. Phillips, Vincent A. Johnson, Joseph D. Clark, Craig A. Harper, David A. Buehler   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Safety and efficacy of low-temperature RA-flush solution in patients with moderate-to-severe calcified lesions (LOTA-II): a randomized, double-blind, multicenter study

Scientific Reports
Rotational atherectomy (RA) is an effective, mature, and specific treatment for calcified lesions. However, the incidence of RA-related myocardial injury remains high and has not been adequately addressed.
Wei You, Xiang-qi Wu, Zhi-ming Wu, Yi-fei Wang, Tong-tong Shen, Bi Tang, Tian Xu, Liang-hong Ying, De-feng Pan, Song Yang, De-lu Yin, Fei Ye   +11 more
doaj   +1 more source

Impact of an Aged Green Roof on Stormwater Quality and First-Flush Dynamics

Buildings
Green roofs (GRs) are increasingly implemented for stormwater management, and retrofitting conventional roofs is emerging as a key strategy for climate change resilience.
Thiago Masaharu Osawa, Maria Cristina Santana Pereira, Brenda Chaves Coelho Leite, José Rodolfo Scarati Martins   +3 more
doaj   +1 more source

The application of improved flow diverter for first flush management

Water Science and Technology, 2010
The paper presents the investigations on first flush phenomenon based on the total suspended solids (TSS) concentration measurement during selected rainfalls at central part of Czestochowa (Poland) and also the hydrodynamic model of the catchment. The model allows to present the conception of first flush management using an improved flow diverter ...
openaire   +2 more sources