Results 121 to 130 of about 248,175 (294)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Management factors associated with bovine respiratory disease in preweaned calves on California dairies: The BRD 100 study. [PDF]

open access: yes, 2019
The objective of this cross-sectional study was to determine how management practices on California dairies may be associated with bovine respiratory disease (BRD) in preweaned calves.
Aly, Sharif   +10 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Long-term experience of vasomotor instability: A five-year follow-up study of perceived control, coping and distress [PDF]

open access: yes, 2002
Objectives: Vasomotor instability can be a long-term feature of the post-menopause yet little is known about how women cope. This study followed up a group of women over five years, to examine whether current levels of flush-related distress/discomfort ...
Reynolds, F
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Insert facing tool [PDF]

open access: yes, 1974
A manually actuated tool for facing the exposed end of an insert installed in a honeycomb panel is described. Several cutting bits are held in a round body portion that is rotated around the end of a stud to provide the cutting action.
Abernathy, W. J., Snoddy, L. G.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Impact of meteorological and processing factors on metabolite composition of Darjeeling tea

open access: yesJournal of Analytical Science and Technology
Meteorological and edaphic factors significantly affect the first flush metabolite composition of Darjeeling tea, impacting flavor, nutrition, and customer preferences. The Camellia sinensis var.
Dwaipee De   +8 more
doaj   +1 more source

Sunflower seed hull: Its value as a broad mushroom substrate [PDF]

open access: yes, 2016
Sunflower (Heliantus annus) seed hull (SSH), an abundant and cheap lignocellulosicresidue from edible oil-seed industries, was evaluated as an alternative substrate formushroom cultivation.
Curvetto, Nestor Raul   +2 more
core  

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