Results 61 to 70 of about 29,704,411 (285)

Engineering criticality analysis on an offshore structure using the first- and second-order reliability method

International Journal of Naval Architecture and Ocean Engineering, 2016
Due to the uncertainties related to the flaw assessment parameters, such as flaw size, fracture toughness, loading spectrum and so on, the probability concept is preferred over deterministic one in flaw assessment.
Beom-Jun Kang, Jeong-Hwan Kim, Yooil Kim
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

AK-FOCM: Integration of active learning Kriging with first order control variates reliability method

Results in Engineering
First-Order Control variates reliability Method (FOCM) has been newly developed. This approach is employed to solve nonlinear and high-dimension problems with small failure probability.
Ala Ameryan, Mansour Ghalehnovi, Mohsen Rashki   +2 more
doaj   +1 more source

Analysis of passing sight distance using first-order reliability method

, 2018
Current passing sight distance requirements for two lane highways by the American Association of State Highway and Transportation Officials are based on field studies conducted between 1938 and 1941 which use deterministic values for its design variables
Andres Serrano (13949652)
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A new adaptive response surface method for reliability analysis [PDF]

, 2013
Response surface method is a convenient tool to assess reliability for a wide range of structural mechanical problems. More specifically, adaptive schemes which consist in iteratively refine the experimental design close to the limit state have received ...
Salaün, Michel, Petitjean, Frank, Roussouly, Nicolas   +2 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Response Extremes of Floating Offshore Wind Turbine Based on Inverse Reliability and Environmental Contour Method

Journal of Marine Science and Engineering
Floating structures are subject to complex marine conditions. To ensure their safety, reliability analysis needs to be conducted during the design phase. However, because of the complexity of traditional full long-term analysis, the environmental contour
Da Li, Botao Xie, Tao Liu, Zhuolantai Bai, Bigui Huang, Junrong Wang   +5 more
doaj   +1 more source

A Comparative Study of First-Order Reliability Method-Based Steepest Descent Search Directions for Reliability Analysis of Steel Structures

Advances in Civil Engineering, 2017
Three algorithms of first-order reliability method (FORM) using steepest descent search direction are compared to evaluate the reliability index of structural steel problems which are designed by the Iranian National Building code.
Hamed Makhduomi, Behrooz Keshtegar, Mehdi Shahraki   +2 more
doaj   +1 more source