Results 151 to 160 of about 19,150,051 (295)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

First Longitudinal Analysis of the Immunological Mechanism at Play in Uterus Transplantation

Transplantation Direct
Marie Carbonnel, PhD, Remy Villette, PhD, Maxime Petit, PhD, Nadine Tarantino, BS, Veronique Morin, BS, Angélique Vinit, MS, Emmanuel Roux, MS, Morgan Tourne, MD, Camélia Radulescu, MD, Zakhia El Beaino, MD, Mathilde Le Marchand, MS, Renaud Snanoudj, PhD, Catherine Racowsky, PhD, Martin Larsen, PhD, Mats Brännström, PhD, Jean-Marc Ayoubi, PhD, Vincent Vieillard, PhD   +16 more
doaj   +1 more source

Attention and Word Learning (@WL) study: protocol for a longitudinal study examining early predictors of coordinated visual attention and word learning in preterm and full-term infants. [PDF]

BMJ Open
Fu X, Goldschlager J, Murphy H, Hu J, Yurkovic-Harding J, Yu C, Bradshaw J.   +6 more
europepmc   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Play vocalizations induce affective bias in reward learning and memory in orangutans. [PDF]

Biol Lett
Laméris DW, Allen C, Lyn H, Martin CF, Nelson EK, Nelson XJ, Taylor AH, Cartmill EA.   +7 more
europepmc   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

More than gaming: Examining executive functions in esports players. [PDF]

PLoS One
Yalçıner S, Özdayı N.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Patient and Public Involvement and Engagement Approach to Co-Design a Walking Football Intervention for People with Chronic Breathlessness. [PDF]

Healthcare (Basel)
Bradford C, Suri S, Loughran KJ, Martin D, Robertson N, Edwards J, Harrison SL.   +6 more
europepmc   +1 more source