Results 71 to 80 of about 3,304,244 (309)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Duchamp, childhood, work and play: the vernissage for first papers of surrealism, New York, 1942 [PDF]
, 2014 Visitors to the opening of the First Papers of Surrealism exhibition in New York in 1942 were disorientated, not only by Marcel Duchamp’s famous ‘mile of string’ installation, but also by the presence of a group of children who, at Duchamp’s instigation,
Hopkins, David
core
Order of first-play in simulated versus monetary gambling. [PDF]
J Behav Addict, 2023 Russell AMT +6 more
europepmc +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Неофилология, 2016 The poetic manner of satire novella by M.A. Bulgakov “The Fatal Eggs” is analyzed. The necessity of such analysis is caused by difficulty and richness of the text, its coding and not full cognition of its theatre basis in science, synthetic links with ...
Vladimir Viktorovich Kolchanov
doaj
Frontiers in Public HealthIntroductionDrama-based simulations and role-playing are increasingly integrated into school-based first aid education, as they enable students to rehearse emergency response skills within controlled and realistic environments.
Cristina Dumitru +14 more
doaj +1 more source
Children with Motor Impairments Play a Kinect Learning Game: First Findings from a Pilot Case in an Authentic Classroom Environment [PDF]
Interaction Design and Architecture(s), 2014 This paper presents the first very positive findings from an empirical study about the effectiveness of the use of a Kinect learning game for children with gross motor skills problems and motor impairments.
Symeon Retalis +3 more
doaj