Results 91 to 100 of about 3,304,244 (309)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Enhancing knowledge and attitudes towards play and the play environment among Thai nursery workers [PDF]

open access: yes, 2013
With the increased number of childcare centres in Thailand, the role of nursery workers has become pivotal to promoting optimal child development. The importance of learning though play is generally not recognised as an important factor in promoting ...
Sudjainark, Sompratthana
core  

Supporting triple-play communications with TDuCSMA and first experiments

open access: yes2014 IEEE Wireless Communications and Networking Conference (WCNC), 2014
This work addresses the implications of using the Time-Division Unbalanced Carrier Sense Multiple Access (TDuCSMA) coordination function to support triple-play services. Firstly, the theoretical background of TDuCSMA is reported, presenting its advantages and discussing its full compliance with the IEEE 802.11 standard. Secondly, a prototype of TDuCSMA
Andrea Vesco   +2 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Children’s play and democratic culture [PDF]

open access: yes, 2018
Children’s play has figured on innumerable occasions as one of the principal focal points for research on different approaches to human development.
Camas Garrido, Laura
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

<原著>"play"と共起するスポーツの意味的制限(人文社会科学系) [PDF]

open access: yes, 2003
The verb "play" can take nouns expressing various kinds of sport as its object: play tennis, play baseball, etc. But not all can occur with "play": *play boxing, *play camping.
平井, 美津子   +3 more
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Family play-learning through informal education: Make and play activities with traditional Thai toy activities at a science museum [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThis thesis charts the outcomes of family play-learning through make-and-play activities with traditional Thai toys activities (TTTA).
Kanhadilok, Peeranut
core  

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