Results 91 to 100 of about 19,150,051 (295)

Sociodramatic play of kindergarten and first grade children.

, 1979
The purpose of this study was to examine the effects of modeling on the sociodramatic play of kindergarten and first grade subjects enrolled in an elementary school receiving Title I funding.
Weddle, Charles D.
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Playing and being well: A review of recent research into children’s play, social policy and practice, with a focus on Wales

Commissioned by Play Wales, this extensive literature review considers contemporary research into childhood studies, relevant policy studies, the relationship between playing and being well, children's play patterns and examples of interventions to ...
Tawil, Ben, Russell, Wendy K, Barclay, Mike   +2 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Multistakeholder perspectives on children’s play and the systemic factors that influence it across 12 low- and middle-income countries

Humanities & Social Sciences Communications
Children’s play in early childhood is not purely natural and inherent, but shaped by interpersonal, sociocultural, political, and economic factors.
Olivia Iannelli, Aila Naderbagi, Adam Poulsen, Mafruha Alam, Yun J. C. Song, Gabrielle Hindmarsh, Ian B. Hickie, Haley M. LaMonica   +7 more
doaj   +1 more source

From screens to systems: Why quality content still matters in the age of AI?

Современное дошкольное образование
Background. As AI becomes embedded in children’s lives, from entertainment to learning, the role of content is transforming—from passive consumption to active, system-embedded dialogue. Methods.
Evren Yigit
doaj   +1 more source

How are the relationships between researching play and children changing? [PDF]

, 2020
Play does not happen in a sealed vacuum, and it is practised in myriad ways across time and cultures. One way of thinking about research in the field is how shifts in culture, politics, policy and environment change how children play and how adults ...
El Gemayel, Sandra, Salema, Yaspia, Jones, Phil, Flewitt, Rosie   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source