Results 101 to 110 of about 3,304,244 (309)

START TO PLAY TENNIS LIKE INCETIVE TO DEVELOPMENT SPORTS IN MONTENEGRO [PDF]

Sport Mont, 2006
At the end of 19 centuries tenis like popular game has srarted to play in Vojvodina. At 1880 tennis grassy courts was built in Senta and from that year it started to play in Vojvodina.
Dimitrije Rašović
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Towards Securing Sufficient Play Opportunities: A short study into the preparation undertaken for the commencement of the second part of the Welsh Government’s Play Sufficiency Duty to secure sufficient play opportunities [PDF]

, 2014
This report is of a small-scale piece of research that re-engaged with stakeholders in an earlier research project ('Leopard Skin Wellies, a Top Hat and a Vacuum Cleaner Hose) into the commencement of the first part of the Play Sufficiency Duty, Section
Russell, Wendy K, Lester, Stuart
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Do soccer players play the mixed-strategy Nash equilibrium? [PDF]

Mixed-strategy Nash equilibrium (MSNE) is a commonly-used solution concept in game-theoretic models in various fields in economics, management, and other disciplines, but the experimental results whether the MSNE predicts well actual play in games is ...
Azar, Ofer H., Bar-Eli, Michael
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Computers and play in early childhood: Affordances and limitations [PDF]

, 2010
The widespread proliferation of computer games for children as young as six months of age, merits a reexamination of their manner of use and a review of their facility to provide opportunities for developmental play.
Verenikina, I., Peterson, R., Herrington, J., Mantei, J.   +3 more
core   +1 more source

Multistakeholder perspectives on children’s play and the systemic factors that influence it across 12 low- and middle-income countries

Humanities & Social Sciences Communications
Children’s play in early childhood is not purely natural and inherent, but shaped by interpersonal, sociocultural, political, and economic factors.
Olivia Iannelli, Aila Naderbagi, Adam Poulsen, Mafruha Alam, Yun J. C. Song, Gabrielle Hindmarsh, Ian B. Hickie, Haley M. LaMonica   +7 more
doaj   +1 more source

From screens to systems: Why quality content still matters in the age of AI?

Современное дошкольное образование
Background. As AI becomes embedded in children’s lives, from entertainment to learning, the role of content is transforming—from passive consumption to active, system-embedded dialogue. Methods.
Evren Yigit
doaj   +1 more source