Results 61 to 70 of about 15,550,123 (259)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The earth’s core: an approach from first principles [PDF]

, 2004
The Earth’s core is largely composed of iron (Fe), alloyed with less dense elements such as sulphur, silicon and/or oxygen. The phase relations and physical properties of both solid and liquid Fe-alloys are therefore of great geophysical importance. As
Gillan, M.J., Vočadlo, L., L. Vočadlo, M. J. Gillan, G. David Price, G. D. Price, D. Alfè, Price, G.D., Alfè, D.   +8 more
core  

First-Principles-Derived Force Fields for CH₄ Adsorption and Diffusion in Siliceous Zeolites

, 2018
Most previous studies on development of force fields for molecules in porous materials focus on prediction of adsorption properties. However, accurately reproducing adsorption data is not sufficient to guarantee the accuracy of other properties, such as ...
David S. Sholl (1270002), Peter I. Ravikovitch (1499728), Rohan Awati (2814997), Salah E. Boulfelfel (5389565), Hanjun Fang (2082991)   +4 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

First Principles Calculation of Residual Resistivity

, 1991
The list of physical properties which are important in the design of materials and which are routinely calculated from first principles within the local density approximation to density functional theory is continually growing.
W. H. Butler, D. M. Nicholson, J. W. Swihart, R. H. Brown, H. Yang, A. Mehta, L. M. Schwartz, P. B. Allen   +7 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Operationalising first year curriculum principles [PDF]

, 2009
This project builds on the First Year Curriculum Project that was carried out at the Queensland University of Technology (QUT) in 2006-2007 (QUT, 2007). One of the objectives of that project was “to develop principles for the Course Development processes
Nelson, Karen J, Clarke, John A., Duncan, Margot E, Creagh, Tracy A., Smith, Judith E, Creagh, Tracy A, Nelson, Karen J., Quinn, Carole, Duncan, Margot E., Smith, Judith E., Clarke, John A   +10 more
core   +1 more source

Superconductivity of thulium substituted clathrate hexahydrides at moderate pressure

Scientific Reports
Due to the BCS theory, hydrogen, the lightest element, would be the prospect of room-temperature superconductor after metallization, but because of the difficulty of the hydrogen metallization, the theory about hydrogen pre-compression was proposed that ...
Hongyu Huang, Chao Deng, Hao Song, Mingyang Du, Defang Duan, Yanhui Liu, Tian Cui   +6 more
doaj   +1 more source

First-principles calculation of optical responses based on nonorthogonal localized orbitals

New Journal of Physics, 2019
Based on ab initio software packages using nonorthogonal localized orbitals, we develop a general scheme of calculating response functions. We test the performance of this method by calculating nonlinear optical responses of materials, like the shift ...
Chong Wang, Sibo Zhao, Xiaomi Guo, Xinguo Ren, Bing-Lin Gu, Yong Xu, Wenhui Duan   +6 more
doaj   +1 more source