Results 151 to 160 of about 13,480,937 (242)

First Responder Virtual Reality Simulator to train and assess emergency personnel for mass casualty response. [PDF]

J Am Coll Emerg Physicians Open, 2023
Kman NE, Price A, Berezina-Blackburn V, Patterson J, Maicher K, Way DP, McGrath J, Panchal AR, Luu K, Oliszewski A, Swearingen S, Danforth D.   +11 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Comparing the incomparable: Population densities and first responder groups through alternate statistics. [PDF]

Resusc Plus
Szvath P, Gloger T, Lauesen CL, Murphy-Jones B, Schnaubelt S.   +4 more
europepmc   +1 more source

Designed to Do Good: Key Findings on the Development and Operation of First Responder Deflection Programs. [PDF]

J Public Health Manag Pract, 2022
Ross J, Taylor B.
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Co-Designing Lived Experience Guide Support for First Responder Mental Health: Defining the Role and Considerations for Implementation. [PDF]

Health Expect
Arjmand HA, Peck T, O'Donnell ML, Sadler N, Savic A, Spinks M, Symons M, Varker T.   +7 more
europepmc   +1 more source

Is the Synovium the First Responder to Posttraumatic Knee Joint Stress? The Molecular Pathogenesis of Traumatic Cartilage Degeneration. [PDF]

Cartilage, 2023
Kwapisz A, Herman K, Momaya A, Piwnik M, Szemraj J, Elphingstone J, Synder M, Grzegorzewski A.   +7 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Pancreatic islet cell calcium ion imaging at single-cell resolution: functional identification of first-responder, highly connected ("hub"), and leader beta-cells. [PDF]

Front Endocrinol (Lausanne)
Delgadillo-Silva LF, Ostinelli G, Provencher-Girard A, Salazar S, Melhem R, Rutter GA.   +5 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source