Results 71 to 80 of about 13,471,873 (289)

Impact of The HEROES Project on First Responders’ Well-Being

Journal of Community Safety and Well-Being, 2020
First responders experience a myriad of stressors (e.g., operational, organizational, personal) over the course of their career. An abundance of empirical evidence shows that the impact of those stressors on first responders’ health, well-being, and ...
Daniel M. Blumberg, Luciano Giromini, Konstantinos Papazoglou, A. Renee Thornton   +3 more
doaj   +1 more source

A Scoping Review of Trauma, Mental Health and First Responders in Australia [PDF]

Exposure to traumatic and/or violent events is an inherent part of the first responder role, which increases the risk of developing acute and chronic mental health symptoms and conditions.
Arena, A, Sutton, C, Gayed, A ; https://orcid.org/, Jones, R, Sutton, Clare, Gayed, A, Usher, K, Arena, A ; https://orcid.org/, Usher, Kim, Ranse, J, Ranse, Jamie, Arena, Andrew, Rice, K, Clegg, Lisa, Jackson, Debra, Rice, Kylie, Clegg, L, Gayed, Aimee, Jackson, D, Jones, Rikki   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Training First Responders Through VR-Based Situated Digital Twins

Computers
This study examines first responder training to deliver realistic, adaptable, and scalable solutions aimed at equipping personnel to handle high-risk, rapidly developing scenarios.
Nikolaos Partarakis, Theodoros Evdaimon, Menelaos Katsantonis, Xenophon Zabulis   +3 more
doaj   +1 more source

Futuristic First Responders [PDF]

Disaster Medicine and Public Health Preparedness, 2016
Zion Tsz Ho, Tse, Sierra, Hovet, Chi-Ngai, Cheung, Isaac Chun-Hai, Fung   +3 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

First responders : care for yourself [PDF]

Infographic with tips for first responders to encourage taking care of yourself one small way each day. The COVID-19 pandemic may be stressful for people.

core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source