Results 151 to 160 of about 14,115,145 (304)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Sr and Ba Yields of the First Generation(s) of Stars: Constraints from Metal-poor Stars

The Astrophysical Journal
We present our chemical abundance analysis of 10 new extremely metal-poor stars with −4.05 ≤ [Fe/H] ≤ −2.33, based on high-resolution ( R ∼ 28,000) Magellan/MIKE spectra. Eight of our stars have low heavy-element abundances of [Sr/H] 
Sarah Hughes, Anna Frebel, Xiaowei Ou, Alexander Yelland, Felicia Xiao, Jorian Benke, Kali Kraus, Reidyn Wingate, Mohammad K. Mardini   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Observing the First Stars in Luminous, Red Galaxies

, 2010
Modern cosmological simulations predict that the first stars are to be found today in luminous, red galaxies. Although observing such stars individually against a background of younger, metal-rich stars is impossible, the first stars should make their ...
Heap, Sally, Lindler, Don
core  

First Detection of Shock Waves in RRc Stars

The Astrophysical Journal
Although shock waves have been well documented in fundamental-mode RRab stars, their existence in first-overtone pulsator stars, RRc stars, has remained uncertain. Building upon the spectroscopic frameworks established by M. Chadid et al., we present the
Junzhang Li, Merieme Chadid
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Kindling the First Stars. I. Dependence of Detectability of the First Stars with JWST on the Population III Stellar Masses

The Astrophysical Journal
The first Population III (Pop III) stars formed out of primordial, metal-free gas, in minihalos at z > 20, and kickstarted the cosmic processes of reionization and enrichment.
Mia Sauda Bovill, Massimo Stiavelli, Alessa Ibrahim Wiggins, Massimo Ricotti, Michele Trenti   +4 more
doaj   +1 more source

Tracing ωCentauri’s origins: Spatial and chemical signatures of its formation history

Astronomy & Astrophysics
ωCentauri (ωCen), with its unmatched chemical complexity, is the most enigmatic Galactic globular cluster (GC). We combine photometric and spectroscopic catalogs to identify distinct stellar populations within ωCen, investigate their spatial distribution
Dondoglio E., Milone A. P., Marino A. F., Mastrobuono-Battisti A., Bortolan E., Legnardi M. V., Ziliotto T., Muratore F., Cordoni G., Lagioia E. P., Tailo M.   +10 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Bifurcations in bosonic stars: chains and rings from spherical solutions

Journal of High Energy Physics
We study the bifurcation phenomena between spherical and axisymmetric bosonic stars. By numerically solving for the zero-modes of spherical bosonic stars under specific axially symmetric perturbations, we discover that excited state spherical bosonic ...
Chen Liang, Carlos A. R. Herdeiro, Eugen Radu   +2 more
doaj   +1 more source