Results 141 to 150 of about 14,115,145 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
An Analysis of Metallic-line Stars with Emission Lines Based on LAMOST
The Astrophysical JournalAm stars are chemically peculiar A-type stars with weak Ca II K and enhanced metal lines. Emission lines in Am stars are extremely rare and their origin poorly understood.
Yanting He +7 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Population-dependent r-process Scatter in the Globular Cluster M15
The Astrophysical Journal LettersMultiple populations, defined by correlations between light element abundances, are an almost ubiquitous property of globular clusters. On the other hand, dispersions among the heavy elements are limited to a few rare clusters. In this Letter, we present
Lauren E. Henderson +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Deutsche Börse FinTech Hub : interview with Hauke Stars
, 2016 Interview with Hauke Stars, Member of the Executive Board Deutsche Börse ...
Stars, Hauke
core
The Carbon-dependent Binary Frequency of CEMP-no Stars
The Astrophysical JournalStudies of the oldest and most metal-poor stars in the Milky Way confirm a common chemical signature of high carbon abundances and subsolar neutron-capture enrichment.
John D. Dixon +17 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source