Results 121 to 130 of about 1,034,573 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Classification of Periodic Variable Stars from TESS
The Astrophysical Journal Supplement SeriesThe number of known periodic variable stars has increased rapidly in recent years. As an all-sky transit survey, the Transiting Exoplanet Survey Satellite (TESS) plays an important role in detecting low-amplitude variable stars.
Xinyi Gao +3 more
doaj +1 more source
, 2019 There is ample evidence in the Milky Way for globular cluster (GC) disruption. Hence one may expect that also part of the Galactic halo field stars may once have formed in GCs.
Grebel, Eva K. +2 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Spectral Evolution of Rotating Population III Stars
The Astrophysical JournalPopulation III (Pop III) stars, the first generation of stars formed from primordial gas, played a fundamental role in shaping the early Universe through their influence on cosmic reionization, early chemical enrichment, and the formation of the first ...
Jake B. Hassan +5 more
doaj +1 more source
A Study of Double- and Multi-mode RR Lyrae Variables
Open Astronomy, 2015 We present the results of our new study of known RR Lyrae variable stars. All observations available for these stars in the Catalina Surveys were analyzed, and double-mode variations were identified.
Khruslov A. V.
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source