Results 221 to 230 of about 107,692 (266)

Strengthening laboratory management towards accreditation in Tanzania: The 13 years of remarkable revolutions in laboratory quality management system. [PDF]

PLoS One
Torokaa PR, Massambu C, Lusekelo J, Julius R, Magesa AS, Majigo M, Joachim A, Kelly ME, Kyalo A, Moremi N.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

An Evaluability Assessment of a School-Based Prevention Program: Promoting Evaluation Capacity Building. [PDF]

Justice Eval J
Krupa JM, Okyere AK, Parker JM.
europepmc   +1 more source

Adjuvant Radiotherapy Following Surgical Excision of Keloids: A Systematic Review of Dose, Fractionation, and Recurrence. [PDF]

Life (Basel)
Wojarska M, Kokot K, Borzyszkowska W, Boczar P, Zalewska Z, Kuryk A, Wojciechowska J, Jankau J.   +7 more
europepmc   +1 more source

Autism stigma, knowledge, attitude, and quality of life predictors among autistic children's caregivers. [PDF]

Front Psychol
Alnajjar HA, Hantira NY, Aljadani J, Almoteri M, Arous M, Alamari M, Albogami M, Alola GA, Alzahrani R, Almotiri R, Wasli L, Bajbair D.   +11 more
europepmc   +1 more source

A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations. [PDF]

PLoS Comput Biol
Tahvili F, Vinck M, Di Volo M.
europepmc   +1 more source

A Rare Complication of Bladder Injury Following Laparoscopic Appendectomy: A Case Report and Literature Review. [PDF]

Cureus
Aamery A, AlMaashani S, Tabook S, Jacob S.   +3 more
europepmc   +1 more source