Results 101 to 110 of about 351,972 (313)

PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development is increasingly integrated across the drug development continuum, enabling more efficient, cost‐effective, and targeted trials while reducing reliance on animal studies. Achieving pharmacoequity requires not only equitable access to medicines but also to the data and knowledge that inform drug development and regulatory ...
Shakir Atoyebi, Prajith Venkatasubramanian, Abdulafeez Akinloye, Oluwasegun Eniayewu, Brookie M. Best, Laura Else, Adeniyi Olagunju   +6 more
wiley   +1 more source

A rare case of uterine rupture in the first trimester of pregnancy: Case report and review of literature

Radiology Case Reports
Uterine rupture is a serious and potentially life-threatening complication. It is commonly a complication that happens in the third trimester of pregnancy. Its occurrence in early pregnancy is very rare.
Chaymae Faraj, Fatima Chait, Yahya Elharras, Nazik Allali, Siham El Haddad, Latifa Chat   +5 more
doaj   +1 more source

Safety of Amlodipine in Early Pregnancy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited. Methods and Results In the present study, we recruited 231 women with chronic hypertension, including those who received amlodipine or
Asako Mito, Atsuko Murashima, Yoshinao Wada, Mai Miyasato‐Isoda, Chizuko A. Kamiya, Masako Waguri, Jun Yoshimatsu, Naho Yakuwa, Omi Watanabe, Tomo Suzuki, Naoko Arata, Masashi Mikami, Shinya Ito   +12 more
doaj   +1 more source

The Effect of Prenatal Stress on Birth Weight: Evidence from the al-Aqsa Intifada [PDF]

No previous study has attempted to estimate the effect of intrauterine exposure to armed conflict, a potential source of stress, on pregnancy outcomes. Drawing on data from the 2004 Palestinian Demographic and Health Survey, we examine the relationship ...
Daniel I. Rees, Hani Mansour
core  

Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure – a pilot study [PDF]

, 2013
The mechanisms of obesity associated reproductive complications remain poorly understood. Endometrial mesenchymal stem-cells are critical for cyclic renewal and uterine function.
Bhandari, Harish, Brosens, Jan J., Gargett, Caroline E., Lucas, Emma S., Murakami, Keisuke, Quenby, Siobhan, Takeda, Satoru, Tan, Bee K.   +7 more
core   +2 more sources

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Prenatal Smoking Cessation and Infant Health: Evidence from Sibling Births [PDF]

This paper uses a unique large panel data of sibling births to provide new evidence on when prenatal smokers must quit smoking to deliver the healthy newborn.
Ji Yan
core  

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source

Towards segmentation and spatial alignment of the human embryonic brain using deep learning for atlas-based registration

, 2020
We propose an unsupervised deep learning method for atlas based registration to achieve segmentation and spatial alignment of the embryonic brain in a single framework.
A Schmidt-Richberg, AI Namburete, BD de Vos, G Balakrishnan, GH Golub, JE Iglesias, LA Shepp, M Kuklisova-Murgasova, M Rousian, RP Steegers-Theunissen, S Liu, X Yang, Y Hu   +12 more
core   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source