Results 91 to 100 of about 6,616,017 (286)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On the first and second variation in the sense of Schramm-Riesz

open access: yesPublicaciones en Ciencias y Tecnología, 2013
In this paper we present a generalization of the concepts of first and second F-variation (where F is a certain sequence of positive convex function defined on [0;+8], in the sense of Schramm-Riesz for normed space valued functions defined on an interval

doaj  

Restoring Poissonian Images by a Combined First-Order and Second-Order Variation Approach

open access: yesJournal of Mathematics, 2013
The restoration of blurred images corrupted by Poisson noise is an important topic in imaging science. The problem has recently received considerable attention in recent years.
Le Jiang   +3 more
doaj   +1 more source

A first glimpse of wild lupin karyotype variation as revealed by comparative cytogenetic mapping

open access: yesFrontiers in Plant Science, 2016
Insight into plant genomes at the cytomolecular level provides useful information about their karyotype structure, enabling inferences about taxonomic relationships and evolutionary origins.
Karolina Susek   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Root and root canal morphology of permanent mandibular first premolars in a Jordanian subpopulation: A cone-beam computed tomography study

open access: yesSaudi Endodontic Journal
Introduction: Understanding variations in roots and canal morphology using both conventional and modern classification systems is essential for the success of endodontic treatment.
Nessrin A. Taha   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Maxillary First Molar With Vertucci Type ⅴ Distobuccal Canals

open access: yesInternational Dental Journal
Introduction: This case report describes a rare Type V root canal configuration in the distobuccal root of a maxillary first molar, addressing the diagnostic and technical challenges posed by complex root canal anatomy in maxillary molars.
Kailiang Tang, Wang Qibao, Du Yi
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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