Results 131 to 140 of about 238,758 (301)

The United States policy in the First World War

open access: yesАмериканська історія і політика, 2017
On the anniversary of the USA entrance to the WWI, let us remind its circumstances. Back in the 19th century, isolationism dominated in the USA despite the expansion іn the Pacific and Caribean basins.
Mykhailo Kirsenko, Tetiana Balabushevych
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Caucasian Front and Azerbaijan during the First World War

open access: yes, 2015
This volume is the result of an international conference held at Sapienza University of Rome in June 2014, which brought together scholars from different countries to re-analyse and re-interpret the events of the First World War, one hundred years after ...
POMMIER VINCELLI, Daniel, Motta
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Joining up: Scotland, cinema and the First World War

open access: yes, 2015
The genesis of this video essay lies in an article that we co-authored on Scotland, cinema and the First World War for NECSUS: European Journal of Media Studies.
Velez-Serna, Maria, Archibald, David
core  

Gendered Humanitarianism: Reconsidering the ethics of war [PDF]

open access: yes, 2011
"The aim of this work is to supplement the usual emphasis on strategic and national issues of war in the interest of theorizing aspects of war from the point of view of individual experience, be the individual a combatant, a casualty, a ..
HUTCHINGS, KJ
core  

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