Results 111 to 120 of about 21,230,810 (314)

Army chaplains in the First World War [PDF]

open access: yes, 2012
In 1914, Church leaders assumed that fighting men would require the ministrations of ordained clergymen close to the front line. The War Office Chaplains' Department had few plans for the deployment of chaplains beyond a general expectation that the ...
Brown, Alison M.
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

A guerra dos corsários – ações navais na costa brasileira durante a Primeira Guerra Mundial (1914-18) [PDF]

open access: yesNavigator, 2017
This article analyses the actions of German raiders in Brazilian coast during World War First. To compound that mosaic, various sources were crossed: old and new, unpublished and published.
Tito Henrique Silva Queiroz
doaj  

They Were There: American Women Physicians and the First World War. [PDF]

open access: yesPerm J, 2020
Marr MC   +4 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

War Aims and the War Aims Discussion (Italy)

open access: yes, 2015
At the outbreak of the First World War, Italian diplomacy did not have a clear vision of the goals to be achieved. Therefore, in negotiations with the countries already involved in the conflict, excessive territorial claims were made.
A. BARAVELLI
core   +1 more source

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