Results 91 to 100 of about 238,758 (301)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Bessarabian clergy during the First World War
Tyragetia, 2013 Bessarabian clergy actively provided moral and material support to the victims of war. It was created a clerical department to help the soldiers and their families.
Silvia Scutaru
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Organisation médicale pendant la première guerre mondiale
Archéopages, 2016 The data obtained from the diagnosis carried out in 2014 in Saint-Parize-le-Châtel, in Nièvre, compared with those obtained from the archives and information provided by local authorities, enabled us to retrace the history of this large American hospital
Nicolas Tisserand, Alexandre Coulaud
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The First World War and the Mobilisation of Biblical Scholarship
, 2018 In January 1917, in the midst of the First World War, a small group of biblical scholars gathered at King’s College London for the inaugural meeting of the newly-formed Society for Old Testament Study (SOTS).
Collins, Matthew A., Matthew A. Collins
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Archipelagic poetry of the First World War
, 2013 This chapter discusses archipelagic poetry of the First World War. It is part of a collection which brings together leading scholars in the field to re-examine First World War poetry in English at the start of the centennial commemoration of the ...
Goldie, David
core
Global War, Global Catastrophe [PDF]
, 2021 Winner of the World War One Historical Association’s 2021 Norman B. Tomlinson, Jr. Prize Global War, Global Catastrophe presents a history of the First World War as an all-consuming industrial war that forcibly reshaped the international environment and,
Abbenhuis, Maartje, Tames, Ismee
core