Results 51 to 60 of about 2,947,762 (304)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analisis Kebutuhan dan Kapasitas Fiskal serta Hubungannya dengan Belanja Pegawai di Kabupaten Tebo

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2015
The ability of fiscal capacity that does not support the fiscal needs allows the fiscal gap . General Allocation Grand which comes from the central government aims to address the fiscal gap . Based on the explanation Regulation No.
Sri Rosmawati, M. Rachmad. R, Zamzami Zamzami   +2 more
doaj  

Fiscal capacity and public health expenditure in Zimbabwe

Cogent Economics & Finance, 2023
Public healthcare financing is important for achieving one of the 2030 Sustainable Development Goals (SDGs), the goal of healthy living and well-being (SDG3).
Tamisai Chipunza, Senia Nhamo
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Fiscal Capacity with Endogenous Access in a Monetary Union

SSRN Electronic Journal, 2022
We study the stabilization properties and welfare implications of a fiscal capacity in a New Keynesian model for a monetary union. A novel feature of the model is that access to the fiscal capacity is conditional on a country's public debt accumulation being sufficiently low.
Dennis Bonam, Marien Ferdinandusse, Pascal Jacquinot   +2 more
openaire   +2 more sources

Updating the UK’s code for fiscal stability [PDF]

, 2004
The 1998 Code for Fiscal Stability sets out the framework within which UK fiscal policy is now set. While having such a code does not make it easier for a Government to meet its fiscal objectives, it may improve the economic credibility of the policy ...
Carl Emmerson, Frayne, C., Frayne, Chris, Christine Frayne, Emmerson, Carl, Sarah Love, Emmerson, C., Love, S., Love, Sarah   +8 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ASSESSING FISCAL CAPACITY THROUGH STAKEHOLDER SATISFACTION IN PUBLIC FUNDING

Север и рынок: формирование экономического порядка
Amid the current crisis, the growing influence of negative factors threatens the fiscal capacity of regions, potentially undermining budgetary policy and the effective realization of individual, public, and national interests.
Tatiana I. Barasheva
doaj   +1 more source

A New EU Economic Governance and Fiscal Framework: What Role for the National Independent Fiscal Institutions (IFIs)? [PDF]

Romanian Journal of European Affairs, 2023
The European Commission’s communication on orientations for a reform of the European Union’s economic governance framework asks the European Fiscal Board (EFB) and national Independent Fiscal Institutions (IFIs) to play a more significant role in it ...
Daniel Dăianu
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source