Results 61 to 70 of about 1,074,968 (254)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Regime Specific Fiscal Effects and the Conditional Role of Institutions: The Case of Mexico

Hitit Sosyal Bilimler Dergisi
Institutional quality is a critical element in explaining the inflationary effects of fiscal deficits. Countries with strong institutions can limit the inflationary effects of fiscal deficits by implementing fiscal discipline more effectively.
Seher Gökpınar, Taha Bahadır Saraç
doaj   +1 more source

Fiscal Discipline and Social Capital: Evidence from Europe during the Last Economic Crisis and Recovery

Eesti Majanduspoliitilised Väitlused, 2013
The purpose of the current paper is to investigate the possible relationship between fiscal discipline and social capital in EU member states during the last economic crisis and recovery, along with the assessment of the initial welfare effects of fiscal
Eve Parts
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Fiscal responsibility laws for subnational discipline : the Latin American experience [PDF]

This paper discusses fiscal responsibility laws in Latin America, with special attention to their provisions for fiscal discipline by subnational governments. It discusses why and when such laws might be useful-to help resolve the coordination problem in
Webb, Steven B.
core  

THE FISCAL FEDERALISM AND THE GOOD ECONOMIC GOVERNANCE IN EUROPEAN UNION [PDF]

Global Economic Observer, 2013
The research objectives aim to analyze the advantages and the disadvantages of the fiscal federalism, in order to identify the model of economic governance that will increase the quality and efficiency in public intervention.
Alina Ligia Dumitrescu
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Government Budget Deficits and the Development of the Bond Market in Pakistan: Issues and Challenges

Lahore Journal of Economics
This article examines how better discipline can be brought to fiscal policy, first, through enhanced institutional checks and balances, and second, through better market discipline.
Jamshed Y. Uppal
doaj  

Poor Quality of Fiscal Forecasts as a Trigger for Fiscal Imbalance in the European Union Countries – The Scale and Methods of Limiting It

Problemy Zarządzania, 2019
The economic crisis revealed the imperfections of the solutions aimed at maintaining fiscal discipline among Member States. Therefore, measures are taken at the EU level to strengthen the institutional aspects of a budgetary process that is based on ...
Sławomir Franek, Marta Postuła
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source