Results 51 to 60 of about 22,171 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Jurnal Tata Kelola dan Akuntabilitas Keuangan NegaraRecurring fiscal deficits and liquidity constraints among Indonesian local governments have raised concerns regarding short-term fiscal sustainability and governance quality.
Abdurahman Abdurahman
doaj +1 more source
Health Science Reports, 2023 Background and Aims Lower‐ and middle‐income countries have decentralized decision‐making at the community level, as well as community governance structures, to encourage community participation in governance processes, particularly in primary healthcare
Anosisye M. Kesale +4 more
doaj +1 more source
Are Fiscal Adjustments Less Successful in Decentralized Governments? [PDF]
SSRN Electronic Journal, 2007 Abstract A common political claim is that decentralized governments undermine policy-makers' ability to resist fiscal imbalance. This paper examines how fiscal centralization influences the likelihood of a successful fiscal adjustment. Using a panel of Swiss cantons from 1981 to 2001, we empirically investigate the determinants of successful long ...
Christoph A. Schaltegger, Lars P. Feld
openaire +5 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Fiscal Governance Treaty - the Recent Act in the European Play [PDF]
Risk in Contemporary Economy, 2012 The new paradigm that affects the current doctrine is particularly focused on building a strong community and it is also motivated by the intention of saving the Lisbon Treaty with its establishing the European Constitution. In the series of the numerous
Monica SUSANU
doaj
Productive Government Expenditure and Fiscal Sustainability [PDF]
FinanzArchiv, 2011 We consider an overlapping-generations model in which public spending directly contributes to an increase in productivity, as in the model of Barro (1990), and in which the government maintains constant ratios of public spending to GDP and of debt issuance to public spending.
openaire +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source