Results 61 to 70 of about 22,171 (312)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Committed to Deficit: The Reverse Side of Fiscal Governance [PDF]

open access: yes
Common wisdom dictates that fiscal governance (i.e. procedural fiscal rules) improves fiscal discipline. We rather find that selected fiscal constraints protect the coalitional status quo from logrolling.
Martin Gregor
core   +1 more source

Governance and Fiscal Federalism in Sudan, 1989–2015: Exploring Political and Intergovernmental Fiscal Relations in an Unstable Polity [PDF]

open access: yes, 2017
This report analyses the implementation and impact of decentralisation in Sudan: To what extent has the efforts to implement decentralisation policies actually devolved power and fiscal resources to sub-national levels, for the benefit of the local ...
Gadkarim, Hassan Ali   +1 more
core   +1 more source

Digital Transition in Public Financial Management: A Comparative Study of Strategies, Success Factors, and Challenges in Thailand and Singapore

open access: yesAsian Review of Public Administration
In the first quarter of the 21st century, digital transformation emerged as a key catalyst for reshaping public administration systems across Asia. This study examines the transition of public financial management (PFM) systems toward digitalization in ...
Dhanabhadr Sookhdee
doaj   +1 more source

EU governance in the run-up to 2025: A Joint Budgetary Procedure

open access: yesPerspectives on Federalism, 2016
The Euro Area (Eurozone, or EZ) is navigating uncharted waters; it has started, in slow motion, to slide towards a fiscal federation, while still lacking both the fiscal capacity and the democratic qualification to achieve this goal.
Nicoli Francesco
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Fiscal Policy Coordination in Europe [PDF]

open access: yes
A fundamental overhaul of EU economic governance is needed. The most important reform is a strengthening of national fiscal frameworks, including the establishment of independent fiscal watchdogs in Member States that do not yet have such institutions ...
Calmfors, Lars
core   +1 more source

European Fiscal Policy Coordination and the Persistent Myth of Stabilization [PDF]

open access: yes, 2007
[From the introduction]. Institutional and ideological influences are not as important as they might seem at first glance. Seen from Bologna, there are good reasons to doubt the mainstream critique of European macroeconomic governance.
Jones, Erik.
core  

Urban governance and finance in India. [PDF]

open access: yes
Over 330 million people live in India's cities; 35 cities have a population of over a million and three (Mumbai, Delhi, and Kolkata) of the 10 largest metropolises in the world are in India.
M. Govinda Rao, Bird, Richard M.
core   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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