Results 91 to 100 of about 10,306 (261)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Quantifying Institutional Fiscal Discipline – Development and Application of the Fiscal Rule Strictness Index (FRSI) in Germany, the USA, and the Czech Republic (2000–2024) [PDF]

ACTA VŠFS
Background - Assessing fiscal discipline is often based on observed outcomes such as debt and deficit levels. However, these indicators reflect policy results rather than the underlying institutional design of fiscal rules.
HOLZMANN, Linus
doaj   +1 more source

The Economics of Fiscal Rules and Debt Sustainability. [PDF]

Inter Econ, 2022
Beetsma R.
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Public Finance, Fiscal Rules and Public-Private Partnerships: Lessons for Post-COVID-19 Investment Plans. [PDF]

Comp Econ Stud, 2023
Cepparulo A, Eusepi G, Giuriato L.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Fiscal Rules in Latin America: A Survey [PDF]

SSRN Electronic Journal, 2012
This survey first discusses general characteristics, advantages, and disadvantages of different types of fiscal rules. It then reviews the experience with fiscal rules in seven Latin American countries. Only Chile targets cyclically adjusted indicators although Colombia is going the “Chilean way” and the Mexican rule offers some stabilization ...
openaire   +2 more sources

Deep Roots of Fiscal Behavior

Journal of Banking and Financial Economics, 2014
This paper investigates the determinants of fiscal policy behavior and its time-varying volatility, using panel data for a broad set of advanced and emerging market economies during the period 1990–2012.
Serhan Cevik, Katerina Teksoz
doaj   +1 more source

Technocratic economic governance and the politics of UK fiscal rules. [PDF]

Br Politics, 2023
Clift B.
europepmc   +1 more source