Results 91 to 100 of about 1,606,303 (302)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Fiscal Rules and Macroeconomic Stability [PDF]
In this paper we analyze the impact of fiscal rules on the effectiveness of fiscal policy as a macroeconomic stabilizing instrument. First, we review the available evidence on the effects of fiscal policy to affect output in the short run and real ...
Javier Andres, Rafael Domenech
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Fiscal Rules versus the Financial Condition of EU Local Government Units
Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2023 The financial crisis and significant deterioration of public finances have led to the strength- ening of instruments aimed at ensuring the financial stability of the state, including fiscal rules.
Elżbieta Malinowska-Misiąg
doaj
Fiscal Transparency and Policy Rules in Poland [PDF]
This paper discusses the link between the deficit bias in public finance and institutional settings. The Polish experience is put in a wider context and provides an extensive discussion of possible institutional reforms that may be implemented to ...
Jens Hölscher +2 more
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
TOWARD A STRONGER FISCAL CONVERGENCE AND DISCIPLINE FOR EUROPE – HOW FAR ARE WE? [PDF]
Annals of the University of Oradea: Economic Science, 2016 Economies frequently pursue policies that tend to lead to fiscal crises, usually sustained by deficits and high public debt levels. First, states borrow in order to sustain their economies, thus accumulating debt and deficits, then are submitted to ...
Florin-Alexandru Macsim, Florin Oprea
doaj
Tying Hands Is Not Commitment: Can Fiscal Rules and Institutions Really Enhance Fiscal Discipline? Bruegel Working Papers, 2007/01, January 2007 [PDF]
, 2007 Visiting Bruegel Scholar Xavier Debrun discusses the role of fiscal institutions, including budget rules and non-partisan agencies, in enhancing fiscal ...
Debrun, Xavier., Debrun, Xavier
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source