Results 71 to 80 of about 2,686,558 (392)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

DETERMINANTS OF FISCAL RULES IMPLEMENTATION – AN EU CASE STUDY [PDF]

Annals of the University of Oradea: Economic Science, 2017
This paper examines the implications of EU treaties, EU accession and other significant variables on the implementation of fiscal rules by EU states at a national level, sample period being years 1994-2015.
Onofrei Mihaela, Macsim Florin-Alexandru, Oprea Florin   +2 more
doaj  

Fiscal Rules: Historical, Modern, and Sub-National Growth Effects

Social Science Research Network, 2020
We examine how fiscal rules influence economic growth. The results show that constitutional fiscal rules promoted growth from the Industrial Revolution until World War II (1789–1950) and also increased modern economic growth (1985–2015).
Klaus Gründler, Niklas Potrafke
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Fiscal aspects of the European monetary integration [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu, 2014
Along with the introduction of the euro as a single currency, importance of respecting the fiscal aspects which determine longevity of the monetary arrangement is recognized.
Golubović Srđan
doaj   +1 more source

Do we need fiscal rules? [PDF]

Revue de l'OFCE, 2013
The public finances crisis has brought binding fiscal rules proposals back to the forefront. The paper analyses their justifications and specifications, either in a classical or in a Keynesian framework. In the recent period there is no evidence that public deficits were caused by fiscal indiscipline and induced too high interest rates; there is no ...
Catherine Mathieu, Henri Sterdyniak
openaire   +9 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Sustainability Dilemma: Fiscal Rules, Institutional Quality, and Economic Outcomes in the EU

Systems
Given that the European Union is facing complex fiscal challenges arising from recent crises, understanding the impact of fiscal rules, institutional governance, and economic performance is critical.
Oana-Ramona Lobonț, Denisa-Andreea Șelaru, Cristina Criste, Andreea Florentina Crăciun, Sorana Vătavu, Petru Marin Ștefea   +5 more
doaj   +1 more source

Fiscal Rules and Economic Size in Latin America and the Caribbean

, 2020
Following the collapse of commodity prices in Latin America and the Caribbean (LAC) in 2014-15, many countries in the region were unable to cushion the impact of the shock in order to experience a more gradual adjustment, to a large extent because they ...
F. Blanco, P. Saavedra, Friederike N. Koehler-Geib, Emilia Skrok   +3 more
semanticscholar   +1 more source

Fiscal Rules, Fiscal Institutions, and Fiscal Performance [PDF]

Economic and Social Review, 2002
This paper was delivered as the inaugural F. Y. Edgeworth Lecture at the Sixteenth Annual Conference of the Irish Economic Association Public spending is a story of some people spending other people?s money. In modern democracies, voters elect politicians to make decisions about public spending for them, and they provide the funds by paying taxes.
openaire   +1 more source