Results 111 to 120 of about 830,683 (322)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Brewers’ Yeast (Saccharomyces cerevisiae) Purified Functional Feed Additives Mitigate Soybean Meal-Induced Enteritis in Atlantic Salmon (Salmo salar) Parr

Aquaculture Nutrition
Soybean meal (SBM) is commonly used in aquafeeds due to its wide availability, reasonable protein content, and cost-effectiveness. However, high SBM inclusion levels in the diets of carnivorous fish, such as Atlantic salmon (Salmo salar), can cause ...
Taofik A. Momoh, Sheu Gbolahan Odu-Onikosi, Folasade Damilola Amulejoye, Joshua Wilson, Benjamin Eynon, Holger Kühlwein, Victor Kuri, Daniel L. Merrifield   +7 more
doaj   +1 more source

The heterogeneous spatial and temporal patterns of behavior of small pelagic fish in an array of Fish Aggregating Devices (FADs) [PDF]

arXiv, 2012
Identifying spatial and temporal patterns can reveal the driving factors that govern the behavior of fish in their environment. In this study, we characterized the spatial and temporal occupation of 37 acoustically tagged bigeye scads (Selar Crumenophthalmus) in an array of shallow Fish Aggregating Devices (FADs) to clarify the mechanism that leads ...
arxiv  

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

N-mixture models with camera trap imagery produce accurate abundance estimates of ungulates

Scientific Reports
Abundance estimates inform ungulate management and recovery efforts. Yet effective and affordable estimation techniques remain absent for most ungulates lacking identifiable marks and inhabiting rugged or highly vegetated terrain. Methods using N-mixture
Grant M. Harris, David R. Stewart, Matthew J. Butler, Eric M. Rominger, Caitlin Q. Ruhl, Daniel T. McDonald, Paige M. Schmidt   +6 more
doaj   +1 more source

I.—On a New Specimen of the Liassic Pachycormid Fish Saurostomus esocinus, Agassiz [PDF]

, 1916
Arthur Smith Woodward
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Measuring and Controlling Fishing Capacity for Chinese Inshore Fleets [PDF]

arXiv
The fishing capacity and capacity utilization for Chinese inshore fleets over the latest 13 years were measured using the DEA method. Relevant models were then established to analyze the relationships between capacity output, capacity utilization, and income, and the function of collecting taxes to control fishing capacity was quantitatively simulated.
arxiv