Results 101 to 110 of about 498,360 (307)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Downward Adjustments in a Cyclical Environment: The Case of Chilean Pelagic Fisheries [PDF]
Often the scale of production of many industrial fisheries in the world shows rigidity vis à vis declines in fish abundance, which on occasions has generated fishing collapse.
Julio Peña-Torres +2 more
core +3 more sources
The fish stocks in Uganda aquatic systems: opportunities and challenges for transformation [PDF]
, 2005 The status of fish stocks in a water body at any one time is a function of several factors affecting the production of fish in that water body. These include: total number (abundance) and biomass(weight) present, growth (size and age), recruitment (the ...
Balirwa, J.S., Kamanyi, J.R.
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Seasonal variability in ichthyoplankton abundance and assemblage composition in the northern Gulf of Mexico off Alabama [PDF]
, 2010 Multiyear ichthyoplankton surveys used to monitor larval fish seasonality, abundance, and assemblage structure can provide early indicators of regional ecosystem changes.
Graham, William M. +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fish distribution in a small domestic water supply reservoir: a case study of Kangimi Reservoir, Kaduna, Nigeria [PDF]
, 2005 A study of the composition and distribution of fish populations in the inshore, surface and bottom water habitats of Kangimi Reservoir showed that the most abundant family was the Cichlidae followed in order of abundance by the familiesCyprinidae ...
Balogun, J.K.
core +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Assessment of stock state for walleye pollock in the Okhotsk Sea in the spring 2013
Известия ТИНРО, 2014 Results of the trawl and ichthyoplankton surveys conducted in the northern Okhotsk Sea in the spring of 2013 are presented. In comparison with 2012, the abundance of walleye pollock decreased in 1.8 times and its biomass - in 1.4 times.
Evgeny E. Ovsyannikov +1 more
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source