Results 81 to 90 of about 501,047 (303)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The blackback flounder and its fishery in New England and New York [PDF]
, 1947 A decline in the abundance of blackback flounders, together with the withdrawal of vessels from this fishery, has resulted in a lowered catch in recent years compared to the peak period 1928 through 1931. Data obtained from U. S.
Perlmutter, Alfred
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Analysis of coral reef health based on the abundance of herbivorous reef fish in the waters of Krueng Raya, Aceh Besar [PDF]
BIO Web of ConferencesThe health and sustainability of coral reefs are influenced by the complex interactions of various organisms, and one indicator of their health is the presence of herbivorous reef fish.
Ulfah Maria +4 more
doaj +1 more source
The composition and resilience of rockpool fish assemblages on the central Hawke's Bay coast New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Ecology at Massey University [PDF]
, 2002 Irregular pagination.Fish assemblages in rockpools on two intertidal platforms on the Central Hawke's Bay coast of New Zealand were studied from June 2000 to March 2001.
Glassey, Nathan John
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Alau reservoir: a multi-dimensional resource base in Borno State [PDF]
, 1999 Aspects of the fishery resources of Alau Reservoir in Maiduguri are reported upon in this paper. It focuses attention on the fishery in terms of fish abundance and potential. It also discusses other resources associated with the fish production.
Bankole, N.O., Okaeme, A.N.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source