Results 101 to 110 of about 501,047 (303)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Estimating the abundance of banded kokopu (galaxias fasciatus gray) in small streams by nocturnal counts under spotlight illumination [PDF]

, 2002
The abundance of banded kokopu (Galaxias fasciatus Gray) in small streams has usually been determined by the labour intensive and invasive method of electric fishing.
Hicks, Brendan J.
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Downward Adjustments in a Cyclical Environment: The Case of Chilean Pelagic Fisheries [PDF]

This paper offers an empirical analysis of harvest functions for the two main Chilean pelagic fisheries, which are characterized by cyclical fish abundance. Two main results are obtained.
Julio Peña-Torres(Georgetown University/Ilades), Sebastián Vergara(ECLAC), Michael Basch(University of Chile)
core   +3 more sources

Assessment of stock state for walleye pollock in the Okhotsk Sea in the spring 2013

Известия ТИНРО, 2014
Results of the trawl and ichthyoplankton surveys conducted in the northern Okhotsk Sea in the spring of 2013 are presented. In comparison with 2012, the abundance of walleye pollock decreased in 1.8 times and its biomass - in 1.4 times.
Evgeny E. Ovsyannikov, Sergey S. Ponomarev   +1 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effects of the hydrological regime on the ichthyofauna of riverine environments of the Upper Paraná River floodplain

Brazilian Journal of Biology
In this work, spatial and temporal variations in the diversity (species richness and Simpson's Diversity Index) and abundance (indexed by the capture per unit effort - CPUE; total and for reproductive groups) of fish from three rivers (Baía, Ivinheima ...
R. Fernandes, AA. Agostinho, EA. Ferreira, CS. Pavanelli, HI. Suzuki, DP. Lima, LC. Gomes   +6 more
doaj   +1 more source

Comparison of the Far-Eastern Seas and North-West Pacific by integral characteristics of pelagic and benthic trawled macrofaun

Известия ТИНРО, 2014
The Bering Sea, ​​Okhotsk Sea, Japan/East Sea and adjacent waters of the Pacific Ocean (mainly within EEZ of Russia) are compared by abundance of pelagic and benthic macrofauna, its species richness, evenness, diversity, and mean weight of animals using ...
Igor V. Volvenko
doaj   +1 more source