FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Effects of physical parameters on fish migration between a reservoir and its tributaries. [PDF]
Sci Rep, 2022 Pfauserová N +5 more
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
FishesThe present study aimed to explore whether water flow velocity could affect the swimming ability and overall energy metabolism of wild Amur grayling (Thymallus grubii). Swimming performance was assessed by measuring critical swimming speed (Ucrit), burst
Cunhua Zhai +6 more
doaj +1 more source
Energies, 2017 Laser Doppler Velocimetry (LDV) measurements, flow visualizations and unsteady Reynolds-Averaged Navier-Stokes (RANS) Computational Fluid Dynamics (CFD) simulations have been carried out to study the turbulent wake that is formed behind a semi-circular ...
S. M. Sayeed-Bin-Asad +2 more
doaj +1 more source
An optimal method for melanoma detection from dermoscopy images using reinforcement learning and support vector machine optimized by enhanced fish migration optimization algorithm. [PDF]
Heliyon, 2023 Liu Q, Kawashima H, Rezaei Sofla A.
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Behavioral Responses of Migratory Fish to Environmental Cues: Evidence from the Heishui River
FishesHydropower infrastructure has profoundly altered riverine connectivity, posing challenges to the migratory behavior of aquatic species. This study examined the post-passage migration efficiency of Schizothorax wangchiachii in a regulated river system ...
Jiawei Xu +10 more
doaj +1 more source
Gaussian-Based Adaptive Fish Migration Optimization Applied to Optimization Localization Error of Mobile Sensor Networks. [PDF]
Entropy (Basel), 2022 Liu Y, Zheng WM, Liu S, Chai QW.
europepmc +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source