Results 91 to 100 of about 146,767 (264)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Biosynthesis of Chitosan Nanocomposite with Myrrh-Mediated Nanosilver for Controlling Skin Pathogenic Microbes

Natural Product Communications
Background: The usages of biosynthesized nanomaterials for microbial pathogens’ fighting have numerous rationales and effectiveness. Skin microbes could acquire drug-resistance that needs innovative approaches for overcoming. Objectives: Phytosynthesized
Hager A. Saad, Mona Assas, Asmaa Abdella, Hend A. Gad, Ahmed A. Tayel   +4 more
doaj   +1 more source

Physical Modification of Whey Protein by Interacting with Methyl Hesperidin: Impacts on Antioxidant Activity and Underlying Mechanism

Biology
In this work, the possibility of enhancing the antioxidant capacity of whey protein (WP) through non-covalent interaction with methyl hesperidin (MH, a hesperidin derivative) was assessed.
Songbo Ma, Shuang Yang, Suqi Yang, Lili Chen, Meilan Yuan, Yong Jiang, Li Zhao, Chunqing Bai   +7 more
doaj   +1 more source

AnchoisFert: A New Organic Fertilizer from Fish Processing Waste for Sustainable Agriculture. [PDF]

Glob Chall, 2022
Muscolo A, Mauriello F, Marra F, Calabrò PS, Russo M, Ciriminna R, Pagliaro M.   +6 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Application of the Gadidae Fish Processing Waste for Food Grade Gelatin Production. [PDF]

Mar Drugs, 2021
Zarubin NY, Kharenko EN, Bredikhina OV, Arkhipov LO, Zolotarev KV, Mikhailov AN, Nakhod VI, Mikhailova MV.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Blockchain Technology for Enhancing Traceability and Sustainability in Fish and Fishery Products: Comprehensive Review

International Journal of Bio-Resource and Stress Management
This study was done to ensure effective fisheries management while protecting marine ecosystems and livelihoods by integrating traceability and sustainability practices.
M. Veena, K. Sravani, K. Dhanapal, G. Praveen Kumar, C. Manaswini, D. Chand Basha   +5 more
doaj   +1 more source

Valorization of Fish Processing By-Products: Microstructural, Rheological, Functional, and Properties of Silver Carp Skin Type I Collagen. [PDF]

Foods, 2022
Guan Y, He J, Chen J, Li Y, Zhang X, Zheng Y, Jia L.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source