Results 101 to 110 of about 309,843 (311)

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

open access: yesAdvanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao   +14 more
wiley   +1 more source

The fishery significance of a pond-type riverbed water-lifting reservoir on small watercourses of the Volga region by the example of the Truev river

open access: yesИзвестия высших учебных заведений. Поволжский регион: Естественные науки
Background. The article considers a special type of reservoirs – partially regulated sections of riverbeds and streams formed by hydraulic structures and other artificial obstacles on the example of the Nadezhdinskiy reservoir on the Truev river in Penza
Alik Yu. Asanov
doaj   +1 more source

Size spectra assess social-ecological impacts on Amazonian fish assemblages

open access: yesEcological Indicators
Finding easily accessible indicators to assess the biodiversity conservation is crucial in regions where long-term monitoring data is deficient. This is particularly true for tropical freshwater ecosystems, which house most of the known fish biodiversity
Victoria J. Isaac   +26 more
doaj   +1 more source

PICES Press, Vol. 7, No. 2, July 1999 [PDF]

open access: yes, 1999
Improving PICES CO2 measurement quality The status of the Bering Sea: July - December 1998 The state of the eastern North Pacific since October 1998 The state of the western North Pacific in the second half of 1998 Paul Henry LeBlond Report on ...

core  

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

open access: yesAdvanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł   +8 more
wiley   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

open access: yesAdvanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang   +5 more
wiley   +1 more source

MONITORING ZOOBENTOS PRODUCTIVITY AT THE REGULATED SURA RIVER SECTION IN PENZA REGION

open access: yesИзвестия высших учебных заведений. Поволжский регион: Естественные науки, 2020
Background. Zoobenthos is an essential component of the fish food base. Therefore, an assessment of fish productivity for this indicator is necessary for any comprehensive fisheries research in water bodies.
A. Yu. Asanov
doaj   +1 more source

Understanding Consumer’s Attitude on Fish Quality and Marketing Aspects in the Greek Market [PDF]

open access: yes
During the last decade the Greek fish market experienced significant changes affecting both the supply and the demand of fish. Fisheries have faced significant problems, such as overfishing and low productivity.
Batzios, Christos   +2 more
core   +1 more source

The Freshwater Biological Association and the International Biological Programme (1961-1976) [PDF]

open access: yes, 1980
The involvement of the FBA in the primary productivity program is ...
Westlake, D.F.
core  

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