Results 121 to 130 of about 451,388 (309)
Chrysene alters the expression pattern of HSP70 genes in mandarin fish
Aquaculture and FisheriesThe heat shock protein 70 (HSP70) in fish plays a crucial role in various physiological and environmental stresses. To reveal the mechanisms of the HSP70 gene response to abiotic stress in mandarin fish (Siniperca chuatsi), we analyzed the HSP70 gene ...
Yufei Liu +3 more
doaj +1 more source
Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]
, 1998 A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM +3 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A taxonomical study on electrophoretic pattern of blood serum protein of some fish of karakaya dam lake [PDF]
Eurasian Journal of Veterinary SciencesIn this study, an electrophoretic comparison of serum blood proteins of two species of fish, Capoeta trutta and Capoeia capoeta umbla, were carried out. Study was carried between june and october in 1997. Using the Random Sampling Method, 92 C.
Muhittin Yılmaz +4 more
doaj
Effects of stress on the immune system of fish [PDF]
, 1994 The effects of stress on the immune system of various fish species including dab Limanda limanda, flounder Platichthys flesus, sea bass Dicentrarchus labrax and gobies Zosterisessor ophiocephalus, were investigated from laboratory and field experiments ...
Farley, S. +2 more
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Loss of redundant gene expression after polyploidization in plants
, 1978 Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25 ...
C. Aragoncillo +20 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source