Results 111 to 120 of about 348,422 (299)
Desain Tungku Alat Perebus Ikan Teri Bagi Masyarakat Kelompok Nelayan Karang Labuang [PDF]
, 2014 In producing salted fish, Karang Labuang fishing communities still use traditional tools, so that the results obtained are not optimal. The boiled process takes a long time, the short life of the tool used, the heat generated is not maximal, and the ...
Nugroho, A. (Agung) +3 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
PLoS ONE, 2019 The release of unwanted fish from purse seines whilst still in the water is termed slipping and may lead to significant mortality following release. The objective of this study was to determine the fish welfare implications of a new slipping methodology ...
Neil Anders +5 more
doaj +1 more source
Bio-Economies of Scope and the Discard Problem in Mulitple Species Fisheries [PDF]
This paper considers the problem of multi-species fisheries management when targeting individual species is costly and at-sea discards of fish by fishermen are unobserved by the regulator.
Singh, Rajesh, Weninger, Quinn
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Farmed fish welfare: stress, post-mortem muscle metabolism, and stress-related meat quality changes
International Aquatic Research, 2019 Over the past few decades, a considerable scientific progress has been achieved in the area of fish welfare at all stages—farming, transportation, various pre-slaughter manipulations, stunning/killing procedures, etc.
Aleksandra Daskalova
doaj +1 more source
Fish Welfare in Public Aquariums and Zoological Collections. [PDF]
Animals (Basel), 2023 Smith SA.
europepmc +1 more source