Results 91 to 100 of about 11,203,193 (300)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Efeito Fisher, incerteza e aversão ao risco uma análise empírica para o Brasil
Economia Aplicada, 2005 This paper aims to estimate a Fisher relation embedded with uncertainty for Brazil during the period Jan/75 - Sept/2000. So far the empirical literature for the Brazilian economy only considered a simple one-toone relation between expected inflation and
Sérgio Rodrigo Vale, Fabiana Rocha
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The long-run Fisher effect: can it be tested? [PDF]
Empirical support for the long-run Fisher effect, a hypothesis that a permanent change in inflation leads to an equal change in the nominal interest rate, has been hard to come by. This paper provides a plausible explanation of why past studies have been
Mark J. Jensen
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 1979 George Fisher and Bill Clinton at Clinton's first gubernatorial victory celebration, with Clinton caricature by Fisher in background. Inscription on recto: "To George Fisher with thanks for your part in my Gala and for putting me on a tricycle!
Fisher, George, 1923-2003
core +1 more source
Information theory and thermodynamic properties for a combined potential model
Scientific ReportsYukawa potential and Hulthẻn potential are very useful potential models with applications in different areas of physics. The present study examined theoretic measure and thermodynamic properties of energy levels and wave functions for a combination of ...
C. A. Onate +4 more
doaj +1 more source
Statistical Measures and Complexity of Supersymmetric Polynomials in Quantum Mechanics
MathematicsWe study information-theoretic and complexity measures for the Dunkl-supersymmetric harmonic oscillator to identify the effect of supersymmetry on these quantities.
Vasil Avramov +4 more
doaj +1 more source