Results 71 to 80 of about 4,485,260 (310)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Penerapan Model Pembelajaran Kooperatif Tipe Think Pair Share (TPS) Dan Model Pembelajaran Kooperatif Tipe Student Team Achievement Division (STAD) Terhadap Hasil Belajar Matematika Siswa Pada Materi Garis Singgung Lingkaran

Numerical: Jurnal Matematika dan Pendidikan Matematika, 2018
This research is to prove whether the learning result of Student Mathematics with cooperative learning model of TPS type is better than the result of student learning of Mathematics with STAD type cooperative learning model on tangent material of circle.
Nurina Kurniasari Rahmawati, Iip Ripati Hanipah   +1 more
doaj   +1 more source

Panel cointegration analysis of the Fisher effect: Evidence from the US, the UK, and Japan [PDF]

This paper analyzes the Fisher effect using a panel of monthly data from January 1990 to December 2010 for three major countries: the United States, the United Kingdom, and Japan.
Yuki Toyoshima, Shigeyuki Hamori
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

George Fisher Self-portrait

, 1990
Pen and ink drawing as Fisher saw himself, sitting at drawing ...
Fisher, George, 1923-2003
core   +1 more source

The False Discovery Rate in Simultaneous Fisher and Adjusted Permutation Hypothesis Testing on Microarray Data

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019
Background and Objectives: In recent years, new technologies have led to produce a large amount of data and in the field of biology, microarray technology has also dramatically developed.
Mohsen Salehi, Issac Almasi
doaj  

An analysis of the ex post Fisher hypothesis at short and long term [PDF]

This paper tests the Fisher effect. The analysis is applied to the U.S.A. It contributes to the existing empirical literature in three ways. First, it considers a panel of short term and long term real interest rates between 1960 and 2008.
Charbel Bassil
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer Immunoediting from Immunosurveillance to Tumor Escape in Microvillus-Formed Niche: A Study of Syngeneic Orthotopic Rat Bladder Cancer Model in Comparison with Human Bladder Cancer

Neoplasia: An International Journal for Oncology Research, 2010
Cancer cells can develop an attenuated immunogenicity and/or create an immunosuppressive microenvironment to prevent tumor eradication by host immune system, the so-called “cancer immunoediting” hypothesis.
Carl-Jørgen Arum, Endre Anderssen, Trond Viset, Yosuke Kodama, Steinar Lundgren, Duan Chen, Chun-Mei Zhao   +6 more
doaj   +1 more source

Can asymmetries account for the empirical failure of the Fisher effect in South Africa? [PDF]

This paper investigates whether unobserved asymmetries can account for irregularities in the Fisher effect for the exclusive case of South Africa. This objective is attained by investigating unit roots within a threshold auto-regressive (TAR) models and ...
Peter Lusanga, Andrew Phiri
core