Results 71 to 80 of about 923,861 (295)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2010 Cancer cells can develop an attenuated immunogenicity and/or create an immunosuppressive microenvironment to prevent tumor eradication by host immune system, the so-called “cancer immunoediting” hypothesis.
Carl-Jørgen Arum +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2019 Background and Objectives: In recent years, new technologies have led to produce a large amount of data and in the field of biology, microarray technology has also dramatically developed.
Mohsen Salehi, Issac Almasi
doaj
Too Good to be False: Nonsignificant Results Revisited
Collabra: Psychology, 2017 Due to its probabilistic nature, Null Hypothesis Significance Testing (NHST) is subject to decision errors. The concern for false positives has overshadowed the concern for false negatives in the recent debates in psychology.
Chris H. J. Hartgerink +2 more
doaj +1 more source
Panel cointegration analysis of the Fisher effect: Evidence from the US, the UK, and Japan [PDF]
This paper analyzes the Fisher effect using a panel of monthly data from January 1990 to December 2010 for three major countries: the United States, the United Kingdom, and Japan.
Shigeyuki Hamori, Yuki Toyoshima
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Neutral Aggregation in Finite Length Genotype space
, 2016 The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness.
Houchmandzadeh, Bahram
core +3 more sources
An examination of the Fisher Hypothesis: the case of Turkey
Applied Economics, 2008 This study examines the famous Fisher Hypothesis (FH) for Turkey. FH asserts that nominal interest rates adjust on a one-to-one basis to expected changes in inflation rates. Using the Johansen cointegration method for the Turkish monthly interest rate and inflation rate data, we find that it is possible to determine the long-run relationship—but not ...
Gül, Ekrem, Açıkalın, Sezgin
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Structural Breaks, Inflation and Interest Rates: Evidence for the G7 countries [PDF]
This paper challenges the commonly used unit root/cointegration approach for testing the Fisher effect for the economies of the G7 countries. We first prove that nominal interest and inflation rate can be better represented as being broken trend ...
Antonio Montañes +2 more
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