Results 141 to 150 of about 149,808 (268)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Some population parameters of three flatfish species (<i>Arnoglossus laterna</i>, <i>Monochirus hispidus</i>, and <i>Microchirus ocellatus</i>) from Güllük Bay, southern Aegean Sea. [PDF]

PeerJ
Cerim H, Yapıcı S, Yılmaz Ö, Gülşahin A, Soykan O, Reis İ, Yalgın F.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Integrated ocean governance is needed in the Southwest Atlantic Ocean to foster fisheries, conservation and resilience to climate change. [PDF]

Discov Ocean
Palacios-Abrantes J, Llompart F, Cardoso LG, Defeo O, Gianelli I, Jaureguizar AJ, Lopes PFM, Perez JAA, Piccolo NIP, Piola AR, Polejack A, Prado LF, Saraceno M.   +12 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Assessing the status and challenges of vulnerability to viability transitions: small-scale fisheries in the transboundary Sundarbans mangrove forest. [PDF]

NPJ Ocean Sustain
Miah MR, Nayak PK, Pittman J, Singh SJ, Chuenpagdee R.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Underestimated barrier effects of ocean fronts shape global fishery distribution. [PDF]

Nat Commun
Xing Q, Gao Z, Ito SI, Yu H, Liu B, Zhang H, Chen X, Yu W.   +7 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Parasite Richness and Host Condition in <i>Caranx caballus</i> (Green Jack): Insights from Artisanal Fisheries of the Eastern Tropical Pacific. [PDF]

Animals (Basel)
Córdoba-Rojas DF, Giraldo A.
europepmc   +1 more source