Results 61 to 70 of about 143,595 (226)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

What You Know is Who You Know? Communication Patterns Among Resource Users as a Prerequisite for Co-management

Ecology and Society, 2006
The social networks is one factor determining the flow of information within communities and as such may be important in determining successful implementation of community based management. We mapped the social network used for communication of knowledge
Beatrice Crona, Örjan Bodin
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

eDNA Sampling Systems for Salmon Ecosystem Monitoring

Environmental DNA
Environmental DNA (eDNA) is transforming the way aquatic ecosystems are monitored and managed by scientists, resource managers, ENGOs, First Nations communities, and citizen scientists alike.
Christoph M. Deeg, Robert G. Saunders, Christopher Tam, Karia Kaukinen, Shaorong Li, Arthur L. Bass, Uu‐a‐thluk Fisheries, Kristina M. Miller   +7 more
doaj   +1 more source

Sustaining Aquatic Ecosystems in Boreal Regions

Ecology and Society, 1998
Few boreal waters are managed in a sustainable manner, because cumulative effects of a variety of human activities are not considered. Fisheries and water quality have declined in most large water bodies of the southern boreal zone.
David Schindler
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A fisher's perspective: Using half a century of local fisher knowledge to identify socio‐economic, ecological and legislative trends influencing angelshark (Squatina squatina) records in Wales

People and Nature
The evolution of marine fisheries has broadly influenced the ecology, distribution and abundance of coastal elasmobranchs. However, quantifying these interactions remains a challenge due to the scarcity of historical records.
Francesca C. Mason, Jake Davies, Surshti Patel, Ben Wray, Charlie Bartlett, Michael Davies, Rowland Sharp, Carl Worrall, Jim Evans, John O'Connor, Sarah Davies, Alice Chamberlain, Charlotte Pike, Kathryn E. Whittey, Claire Collins, Matthew Gollock, Joanna Barker, David J. Curnick   +17 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Studying Kenai River Fisheries’ Social-Ecological Drivers Using a Holistic Fisheries Agent-Based Model: Implications for Policy and Adaptive Capacity

Fishes, 2019
Alaska’s salmon fisheries are one of the more intensely managed natural resources in the world. The state’s salmon fisheries support recreational, subsistence, and commercial harvest with multiple billions of dollars flowing into the economy,
Maxwell Franklin, Martin Cenek, E. Jamie Trammell   +2 more
doaj   +1 more source