Results 141 to 150 of about 88,772 (298)
Advanced Science, EarlyView.This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng +13 more
wiley +1 more source
Haiyang Kaifa yu guanliChina’s demand for aquatic products is steadily increasing, however, unchecked expansion of production will inevitably exceed natural carrying capacity.
LI Zongheng, WEI Youzhou
doaj
Advanced Science, EarlyView.The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo +16 more
wiley +1 more source
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
The contributions by women to fisheries economies worldwide
, 2019 Women make important but often undervalued contributions to fisheries economies globally. Missing these contributions has direct consequences for the sustainability of fisheries and for the millions who depend on fisheries resources worldwide. This work draws on the principles of economics and on other theoretical frameworks and knowledge systems to ...
openaire +1 more source
Advanced Science, EarlyView.Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler +4 more
wiley +1 more source
Advanced Science, EarlyView.AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li +9 more
wiley +1 more source
PLoS ONERed snapper fishing (Lutjanus purpureus) is an important fishing activity for the Brazilian economy due to its export. The scarcity of up-to-date information on this system's ecology, economy, and social characteristics contributes to inefficient ...
Niedja Mescouto +4 more
doaj +1 more source
Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity
Advanced Science, EarlyView.This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini +8 more
wiley +1 more source
Advanced Science, EarlyView.The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang +7 more
wiley +1 more source