Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Multi-objective scenarios analysis for optimizing mariculture spatial allocation: a case study of Lianyungang, China. [PDF]
Sci RepWang Q, Li C, Li Y.
europepmc +1 more source
Taxes, ITQs, Investments, and Revenue Sharing [PDF]
There is a presumption that individual transferable quotas (ITQs) will provide incentives to invest optimally in fishing boats. This paper shows that this is not true when the crew is paid a share of the catch value instead of a parametric wage.
Hannesson, Rognvaldur
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Digital twin of the ocean as a catalyst for blue economy innovation. [PDF]
Natl Sci RevChai F +9 more
europepmc +1 more source
D1.2 Progress towards implementation of the fleet/fishery and indicator frameworks in the North Sea using Fcube [PDF]
, 2009 Hille Ris Lambers, R. +3 more
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Sustainable blue economy: energy consumption and carbon‑neutrality strategies for Albania's marine and fisheries sectors. [PDF]
Carbon Balance ManagMalka L +7 more
europepmc +1 more source
Outstanding Master's Thesis Award: Estimation of Elasticities of Demand for Imported Meat in Russia, by Alexi Soshnin; Master's Thesis Award of Merit: Effective Rural Development Strategies: a Framework for Optimizing Community-Business Matches, by ...
Anonymous
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source