Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Aerospatial remote sensing as catalyst of an operational marine fishery (halieutic) science
, 1991 A brief balance of the attainments and limits in the modern halieutic (fishery biology and economy) field is stricken and shows off the gap between the present management structure and the present problems.
Petit, Michel
core +1 more source
Ecological forecasts for marine resource management during climate extremes. [PDF]
Nat Commun, 2023 Brodie S +8 more
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Quantifying and predicting impacts of salmon ocean fishery closures
The ocean salmon fishery on the US West Coast has faced periodic closures of varying extents in order to protect vulnerable runs. These closures can have serious consequences for fishers and fishing communities, and have necessitated the release of ...
Holland, Dan +2 more
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Incentive Systems for Reducing Bycatch In the Alaska Pollock/Salmon Fishery
The bycatch problem has remained troubling and persistent, even in fisheries that have rationalized their target fisheries. The Alaskan Pollock fishery is an example of a fishery struggling to contain the bycatch of salmon in spite of a transformation of
Wilen, James
core
Knowledge Discovery and Representation for Fishery Forecasting
Energy Procedia, 2011 Hongchun Yuan, Jintao Wang, Xinjun Chen
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source