Results 141 to 150 of about 439,875 (265)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Model selection for forecast combination [PDF]
In this paper it is advocated to select a model only if it significantly contributes to the accuracy of a combined forecast. Using hold-out-data forecasts of individual models and of the combined forecast, a useful test for equal forecast accuracy can be
Franses, Ph.H.B.F.
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Community fishery resources management in Malalison Island, Philippines [PDF]
, 1995 The Community Fishery Resources Management Project, launched in 1991 in Malalison Island, Philippines is a development-oriented research project integrating biology, economics, sociology, engineering, and public administration.
Agbayani, Renato F.
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Optimal Capacity Decisions in a Developing Fishery [PDF]
The problem of estimating optimal fishing capacity for a developing fishery is discussed, using the methods of Bayesian decision analysis. The results obtained indicate that quite good decisions can often be made on the basis of limited prior information
Clark, Colin W. +3 more
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
BIOECONOMIC ANALYSIS OF ALTERNATIVE SELECTION PATTERNS IN THE UNITED STATES ATLANTIC SILVER HAKE FISHERY [PDF]
In this paper a bioeconomic simulation of the U.S. fisheries for silver hake, Merluccius bilinearis, is presented. The model design combines elements of age-structured population and harvest yield models with economics of the silver hake fishery.
Mayo, R.K. +2 more
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Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
High-Grading in a Quota-Regulated Fishery, with Empirical Evidence from the Icelandic Cod Fishery [PDF]
Fishers in quota-regulated fisheries find it to their advantage to discard less valuable fish at sea to increase the value of their catch. A theoretical model describing the high-grading behavior of fishers is presented, and an empirical model is derived
Rickertsen, Kyrre, Kristofersson, Dadi
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source