Results 51 to 60 of about 24,141 (262)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Turning conflict into collaboration in managing commons: A case of Rupa Lake Watershed, Nepal

International Journal of the Commons, 2015
A growing body of literature on the commons has provided fascinating and intricate insights on how some local institutions have successfully managed to avoid a seemingly inevitable “tragedy of the commons” once popularized by Garrett Hardin.
Pashupati Chaudhary, Netra B. Chhetri, Brian Dorman, Tom Gegg, Ram B. Rana, Milan Shrestha, Keshab Thapa, Krishna Lamsal, Surya Thapa   +8 more
doaj   +1 more source

The Importance of Environmental Exposure History in Forecasting Dungeness Crab Megalopae Occurrence Using J-SCOPE, a High-Resolution Model for the US Pacific Northwest

Frontiers in Marine Science, 2020
The Dungeness crab (Metacarcinus magister) fishery is one of the highest value fisheries in the US Pacific Northwest, but its catch size fluctuates widely across years.
Emily L. Norton, Samantha Siedlecki, Isaac C. Kaplan, Albert J. Hermann, Albert J. Hermann, Jennifer L. Fisher, Cheryl A. Morgan, Suzanna Officer, Casey Saenger, Simone R. Alin, Jan Newton, Nina Bednaršek, Richard A. Feely   +12 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Economic Assessment of Meteorological Information Services for Capture Fisheries in Taiwan

Atmosphere
This study evaluates the economic benefits of meteorological information services (MISs) provided by the Central Weather Administration (CWA) in Taiwan, specifically for Taiwan’s capture fishery industry.
Hen-I Lin, Sheng-Jang Sheu, Chu-Wei Chen, Fang-I Wen, Chin-Wen Yang, Je-Liang Liou, Meng-Wei Chen, Jen-Hung Hsu, Yu-Chieh Chang   +8 more
doaj   +1 more source

Ecosystem-based Fishery Management in the Bering Sea [PDF]

, 2014
In the Bering Sea, science-based management of major fisheries is designed to control fishing at levels that maintain stable populations of valuable fish.

core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The effect of long term exploitation by the gill net fishery on the multispecies fish stocks in Kainji Lake, Nigeria, 1969-1997 [PDF]

, 1997
The findings are presented of an assessment made of the gillnet fishery in Kainji Lake, Nigeria from 1969 to the present, on the basis of data sets from commercial and experimental gillnet fishing, with the purpose to detect trends in some key fishery ...
Du-Feu, T.A., Seisay, M.D.B.
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source