Results 81 to 90 of about 3,429,512 (335)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
The U.S. Fishery Conservation and Management Act 1976 - a Plan for Diplomatic Action [PDF]
, 1979 We propose a new framework for the experimental study of periodic, quasi- periodic and recurrent dynamical systems. These behaviors express themselves as topological features which we detect using persistent cohomology.
de Silva, Vin +2 more
core +2 more sources
Economics and Hawaii's Marine Fisheries [PDF]
, 1993 This paper reviews economic research conducted on Hawaii's marine fisheries over the past ten years. The fisheries development and fisheries management context for this research is also considered.
Pooley, Samuel G.
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
The Canadian Fisheries Industry: Retrospect and Prospect
Canadian Political Science Review, 2007 Without question, Canadian domestic policy has had an influence on the development of the fisheries staple industry – from its National Policy to its subsidization of both fishers and, more recently its effort to conserve of fish stocks. In this respect Laxer is correct in allocating “blame” for the current dire status of the fisheries industry where ...
openaire +2 more sources
Flipping the Fishing Business Model on its Head [PDF]
, 2017 This GrantCraft case study, developed for Foundation Center's FundingtheOcean.org portal, explores how the Gordon and Betty Moore Foundation, encouraged collaboration in U.S. West Coast groundfish fishing communities.
Anna Pond
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Measuring the Economic Performance of Australian Fisheries Management [PDF]
Australia recently introduced a revised 'economic' objective to its Fisheries Management Act that has given greater focus to the economic performance of Australian fisheries management.
Rayns, Nick, Read, Kathryn
core +1 more source
Revisiting Maine’s lobster commons: rescaling political subjects [PDF]
, 2012 Calls for cross-scalar theoretical and methodological approaches are not new to commons scholarship. Such efforts might be hastened by channelling poststructuralist and critical theory perspectives through the geographic subfield of political ecology ...
Brewer, Jennifer F
core +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source