Results 51 to 60 of about 30,785 (306)

Seeking sustainability: Employing Ostrom's SESF to explore spatial fit in Maine’s sea urchin fishery

open access: yesInternational Journal of the Commons, 2019
Achieving resource sustainability in complex social-ecological systems requires employing place-based management mechanisms congruent with the underlying temporal, spatial, and functional dynamics of the system in question.
Kimberly L Ovitz, Teresa R Johnson
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Harmonizing the Authority of Fishery Resources Management in the Era of Regional Autonomy Based on Pancasila

open access: yesPancasila and Law Review, 2020
The configuration of fisheries policy before regional autonomy shows the hegemony of the country which adheres to the legal doctrines of collective ownership, centralism, and anti-pluralism. Since the era of regional autonomy, the provincial and district
Mashuril Anwar   +2 more
doaj   +1 more source

Larval Spatiotemporal Distribution of Six Fish Species: Implications for Sustainable Fisheries Management in the East China Sea [PDF]

open access: gold, 2022
Min Xu   +9 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Transboundary Fisheries Management [PDF]

open access: yesThe Korean Journal of International and Comparative Law, 2020
Abstract Malaysia’s unique geographical position, straddling across several seas within the Indian and Pacific Oceans, allows her to play an important role within the set of regional, sub-regional and bilateral arrangements for transboundary fisheries management in the Indo-Pacific theatre.
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Strengthening Supply Chain Management Through Human Capital Development in Isolated Community-Based Fisheries [PDF]

open access: yesE3S Web of Conferences
This article examines the role of human capital development in supply chain management on Bawean Island, an isolated island in Indonesia. This study uses a soft system methodology with purposive sampling, involving in-depth interviews with 15 key ...
Rizkina Fitriana Dina   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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