Results 71 to 80 of about 4,370,794 (311)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Development and Reform of Fishery Subsidies Under the Construction of Ecological Civilization

Haiyang Kaifa yu guanli
Marine fishery plays a vital role in China’s economic system, and the issue of fishery subsidy policy has always been a research hotspot. In the face of the contradiction between the depletion of inland and offshore fishery resources and the growing ...
LI Jinyu, TIAN Tao, LIU Xinshan, YIN Zengqiang, WU Zhongxin, LI Qingxia   +5 more
doaj  

Time-Dependent Quotas for the Southern Bluefin Tuna Fishery [PDF]

It is now officially recognized by the governments of Australia and Japan that the southern bluefin tuna fishery has been overexploited and that harvests must be controlled. A dynamic programming model applicable to multicohort fisheries is developed for
Kennedy, John O.S., Watkins, James W.
core  

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Measuring management success for protected species: Looking beyond biological outcomes

Frontiers in Marine Science, 2016
The complexity of the ocean ecosystem, including the human component, is such that a single fishery may require multiple policy instruments to support recovery and conservation of protected species, in addition to those for fisheries management.
Kathryn D Bisack, Gisele M. Magnusson
doaj   +1 more source

RENT-SEEKING AND PROPERTY RIGHTS FORMATION IN THE U.S. ATLANTIC SEA SCALLOP FISHERY [PDF]

This paper chronicles rent-seeking in the U.S. Atlantic sea scallop fishery, including its influence on property rights formation. Decades of lobbying by the U.S.
Edwards, Steven F.
core  

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Climate change adaptation and the role of fuel subsidies: An empirical bio-economic modeling study for an artisanal open-access fishery.

PLoS ONE, 2019
Climate change can severely impact artisanal fisheries and affect the role they play in food security. We study climate change effects on the triple bottom line of ecological productivity, fishers' incomes, and fish consumption for an artisanal open ...
Kira Lancker, Anna-Lena Deppenmeier, Teferi Demissie, Jörn O Schmidt   +3 more
doaj   +1 more source

Monopsony Processing in an Open-Access Fishery [PDF]

In a recent paper, Clark and Munro (1980) showed that monopsony processing more than offsets the effects of open-access in the harvesting sector of a commercial fishery, and leads to overconservation of the resource.
Stollery, Kenneth R.
core  

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source