Results 71 to 80 of about 11,285 (272)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Известия ТИНРО, 2016 Chemical and ecological state of the Novik Bay waters is described on the data of surveys conducted in summer, autumn, winter, and spring of 2014-2015. Lowered content of dissolved oxygen is noted for summer, with occasional decreasing to 5-6 mg/L that ...
Nadezhda K. Khristoforova +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Some results of researches on pacific herring in the northwestern Bering Sea in 2010-2015
Известия ТИНРО, 2017 The data of pelagic and bottom surveys on pacific herring in the northwestern Bering Sea obtained in 2010-2015 and its stock assessments by different methods are compared.
Sergey V. Loboda, Alexander Yu. Zhigalin
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Baseline studies of biodiversity: the fish resources of Western Indonesia [PDF]
Fishery resources, Fishery surveys, Biological diversity, Baseline studies, Indonesia,
Martosubroto, P. (eds.), Pauly, D.
core
Modelling enforcement and compliance in fisheries: A survey
, 2013 Monitoring and enforcement considerations have been largely ignored in the study of fishery management. This paper discusses this issue with a formal model to show the impacts of costly, imperfect enforcement of law on the behaviour of fishing firms and fisheries management.
Coelho, Manuel +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A trophic model of the coastal fisheries ecosystem off the west coast of Sabah and Sarawak, Malaysia [PDF]
A mass-balance steady-state trophic model of the coastal fisheries ecosystem off the West Coasts of Sabah and Sarawak, Malaysia (10 - 60 m depth) was constructed using the Ecopath software. The ecosystem models were partitioned into 29 ecological/trophic
Man, A. +4 more
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