Results 81 to 90 of about 11,285 (272)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Status of demersal fishery resources in the Gulf of Thailand [PDF]
Data from trawl surveys (1961 - 95) and annual production statistics (1971 - 95) were used to examine the status of demersal fishery resources in the Gulf of Thailand.
Eiamsa-Ard, M. +3 more
core
Assessing the exploitation status of Johnius belangerii in Zhanjiang Bay.
PLoS ONEFishery stock assessment is the basis of fishery management. This study explored the applicability of the Length-Based Spawning Potential Ratio method (LBSPR) to assess the exploitation status of data-limited fisheries.
Siman Deng +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The impacts of environmental forcing on the dynamics of demersal fishery resources of Ghana [PDF]
The dynamics of demersal fish species assemblages and stocks on the continental shelf of Ghana, West Africa were investigated using data from trawl surveys conducted between 1963 and 1990, and in relation to marine environmental and nearshore forcing ...
Koranteng, Kwame Abu
core
Fishery Management Enforcement Gradients to Achieve Fishery Goals
Marine protected areas (MPAs) can allow some fish populations to rebuild within their borders in areas impacted by overfishing, but the effectiveness of reserves is highly dependent on how effectively fishing mortality is controlled, which in turn ...
Kendra A. Karr +3 more
core +1 more source
Revista de Biología Tropical, 2012 The brown sea cucumber fishery is active in the Galapagos Islands since the year 1991 after its collapse in mainland Ecuador. This paper analyzes the Galapagos Sea cucumber fishery over the past decade and the reasons for its management pitfalls and ...
Matthias Wolff +2 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Effects of Individual Vessel Quotas in the British Columbia Halibut Fishery
Implementation of Individual vessel quotas (IVQs) in the British Columbia halibut fishery has provided a unique opportunity to examine the effects of this management technique on a previously intense "derby" fishery. This paper describes the changes that
Wilen, James E. +3 more
core