Results 91 to 100 of about 83,751 (269)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatio‐Temporal Assessment of Fish Biodiversity in High‐Density Cascade Dam Rivers Using Environmental DNA Metabarcoding

Biological Diversity
The biodiversity of rivers with cascade dams undergoes significant changes due to alterations in hydrological conditions caused by the development of hydropower projects.
Changping Jiang, Yanping Zhang, Changwei Jiang, Zijun Su, Tai Wang, Yanyan Du   +5 more
doaj   +1 more source

Effects of Vitamin E on Growth Performance, Biochemical Indices, Antioxidant Capacity, and Ovarian Development in Female Chinese Sturgeon (Acipenser sinensis) Broodstock

Animals
This study investigated the effects of dietary vitamin E (DL-α-tocopherol acetate) supplementation on growth performance, biochemical indices, antioxidant capacity, and ovarian development in female Chinese sturgeon (Acipenser sinensis) broodstock.
Pei Chen, Jing Yang, Baifu Guo, Yacheng Hu, Hongtao Huang, Wei Jiang, Zhiyuan Li, Kan Xiao   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Two new species of Trichomycterus (Siluriformes: Trichomycteridae) from the Rio Itabapoana Basin, south-eastern Brazil

European Journal of Taxonomy
Streams in the Atlantic Forest of Brazil are home to a great diversity of endemic freshwater fishes, but some fish groups are still poorly known. In the last 22 years, our field inventories have recorded some species of the mountain catfish genus ...
Wilson J.E.M. Costa, Maria Anaïs Barbosa, Axel M. Katz   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Comparative Skeletal Morphology and Adaptive Evolution of Three Schizothorax (Actinopterygii: Cypriniformes) Species in Xinjiang Revealed by Micro-CT

Diversity
The genus Schizothorax comprises an important group of freshwater fishes in Xinjiang (China); however, detailed information on their skeletal anatomy remains limited.
Xuyuan Lin, Chengxin Wang, Zhichang Yuan, Qihai Wu, Hao Xu, Bin Huo, Yafan Zhu, Jieya Liu, Yong Song, Shengao Chen   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Chromosome-level genome assembly of Triplophysa bombifrons using PacBio HiFi sequencing and Hi-C technologies

Scientific Data
Triplophysa bombifrons, a species of bony fish localized in China, has largely been understudied genetically, with limited data available beyond its mitochondrial genome. This study introduces a chromosome-level genome assembly for T.
Chengxin Wang, Site Luo, Yong Song, Liting Yang, Xinyue Wang, Shengao Chen   +5 more
doaj   +1 more source