Results 51 to 60 of about 393,096 (313)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Mechanism of Biphasic Activation of NLRP3 Inflammasome in the Fat Greenling (Hexagrammos otakii) Under Hypoxic Stress: From Inflammatory Defense to Pyroptosis Execution

Fishes
Hypoxic stress is an important environmental challenge for aquatic organisms, which is detrimental to fish survival and growth. Specifically, the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) has emerged as a pivotal regulator ...
Yiting Wu, Ling Zhao, Xinying Zhang, Rangman Liu, Dongxu Gao, Junru Su, Lei Peng, Yuan Liu, Yuqing Yan, Zhuang Xue, Wei Wang   +10 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Sequence identification and phylogenetic analysis of the mitochondrial genome of Microphysogobio kiatingensis (Cypriniformes: Cyprinidae)

Mitochondrial DNA. Part B. Resources, 2018
Microphysogobio kiatingensis is endemic freshwater fish of China and mainly distributed in the middle and upper reaches of the Yangtze River. The complete mitogenome of M.
Yuanchao Zou, Junying Zhang, Tao Zhang, Meng Xie, Tian Wu   +4 more
doaj   +1 more source

A histopathologic evaluation of gross lesions excised from commercially important North Altantic marine fishes [PDF]

, 1986
Histopathologic studies of lesions found in commercially important North Atlantic marine fishes are uncommon. As part of a comprehensive Northeast Fisheries Center program ("Ocean Pulse") to evaluate environmental and resource health on the U.S ...
Despres-Patanjo, Linda, Murchelano, Robert A., Ziskowski, John   +2 more
core  

The Immunoglobulins of Cold-Blooded Vertebrates [PDF]

, 2014
Peer reviewedPublisher ...
Chen, Clem, Cone, Cooper, Crouch, Deza, Grey, Hadji-Azimi, Hsu, Kokubu, Leslie, Magor, Malecek, Mansikka, Patel, Schaerlinger, Schaerlinger, Small, Steiner, Turchin, Wilson, Wu, Zapata   +22 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Hindering the biofilm of microbial pathogens and cancer cell lines development using silver nanoparticles synthesized by epidermal mucus proteins from Clarias gariepinus

BMC Biotechnology
Scientists know very little about the mechanisms underlying fish skin mucus, despite the fact that it is a component of the immune system. Fish skin mucus is an important component of defence against invasive infections. Recently, Fish skin and its mucus
Ahmed N. Alabssawy, Mohammed Abu-Elghait, Ahmad M. Azab, Hassan M. M. Khalaf-Allah, Abdelrahman S. Ashry, Ahmed O. M. Ali, Abu-Bakr A. A. Sabra, Salem S. Salem   +7 more
doaj   +1 more source

Metabolic Responses and Oxidative Stress Adaptation Mechanisms of the Pituitary Gland in the Tiger Puffer Under Low-Temperature Stress

Fishes
To explore the induction of low temperature the Tiger Puffer (Takifugu rubripes) In this study, the influence of temperature on the pituitary gland during masculinization was investigated through chronic hypothermia stress experiments.
Yifan Li, Taicheng Li, Meihui Yao, Chuan Li, Zibin Jiang, Hongyu Pan, Wei Wang, Yajuan Li, He Zhou   +8 more
doaj   +1 more source

Ichthyofaunal Diversification and Distribution in Jane\u27s Creek Watershed, Randolph County, Arkansas [PDF]

, 1974
The purposes of this study were to determine the qualitative and quantitative distribution of fishes in the Jane\u27s Creek watershed. Jane\u27s Creek is a clear, spring-fed Ozark stream in northeastern Arkansas.
Fowler, Cheryl Lynn, Harp, George L.
core   +2 more sources