Results 51 to 60 of about 83,751 (269)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mechanism of Biphasic Activation of NLRP3 Inflammasome in the Fat Greenling (Hexagrammos otakii) Under Hypoxic Stress: From Inflammatory Defense to Pyroptosis Execution

Fishes
Hypoxic stress is an important environmental challenge for aquatic organisms, which is detrimental to fish survival and growth. Specifically, the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) has emerged as a pivotal regulator ...
Yiting Wu, Ling Zhao, Xinying Zhang, Rangman Liu, Dongxu Gao, Junru Su, Lei Peng, Yuan Liu, Yuqing Yan, Zhuang Xue, Wei Wang   +10 more
doaj   +1 more source

The complete mitochondrial genome of Ancherythroculter wangi and its phylogeny

Mitochondrial DNA. Part B. Resources, 2018
Ancherythroculter wangi, is a unique freshwater fish and mainly distributed in the upper stream of Yangtze River and its tributary. In this study, the complete mitochondrial genome of A. wangi was first determined.
Yuanchao Zou, Junying Zhang, Meng Xie, Tao Zhang, Qi Deng, Zhengyong Wen   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Telomere-to-telomere reference genome of Rhinogobio nasutus, an endangered endemic fish from the Yellow River

Scientific Data
Rhinogobio nasutus is an endemic fish species native to the middle and upper reaches of the Yellow River in China, renowned for its high economic and nutritional value. However, due to overfishing, human activities, and environmental pollution, it is now
Changping Jiang, Yanyan Du, Zhongyu Lou, Yanping Zhang, Tai Wang   +4 more
doaj   +1 more source

Microbiome baseline for an Arctic sentinel: spatial patterning of nasal and anal microbiomes in ringed seals

Frontiers in Marine Science
IntroductionRinged seals (Pusa hispida) are sentinel species of Arctic change, yet baseline microbiome data across their circumpolar range remain limited.MethodsWe profiled nasal and anal microbiomes from 90 free-ranging ringed seals across eight Arctic ...
Carlos A. Domínguez-Sánchez, Olwyn C. Friesen, Brent G. Young, Tera L. Edkins, Ellen V. Lea, Magali Houde, Stephen D. Petersen, David J. Yurkowski, Holly E. L. Gamblin, Steve H. Ferguson   +9 more
doaj   +1 more source

Sequence identification and phylogenetic analysis of the mitochondrial genome of Microphysogobio kiatingensis (Cypriniformes: Cyprinidae)

Mitochondrial DNA. Part B. Resources, 2018
Microphysogobio kiatingensis is endemic freshwater fish of China and mainly distributed in the middle and upper reaches of the Yangtze River. The complete mitogenome of M.
Yuanchao Zou, Junying Zhang, Tao Zhang, Meng Xie, Tian Wu   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Hindering the biofilm of microbial pathogens and cancer cell lines development using silver nanoparticles synthesized by epidermal mucus proteins from Clarias gariepinus

BMC Biotechnology
Scientists know very little about the mechanisms underlying fish skin mucus, despite the fact that it is a component of the immune system. Fish skin mucus is an important component of defence against invasive infections. Recently, Fish skin and its mucus
Ahmed N. Alabssawy, Mohammed Abu-Elghait, Ahmad M. Azab, Hassan M. M. Khalaf-Allah, Abdelrahman S. Ashry, Ahmed O. M. Ali, Abu-Bakr A. A. Sabra, Salem S. Salem   +7 more
doaj   +1 more source